The handle http://hdl.handle.net/1887/46114 holds various files of this Leiden University dissertation
Author: Tuin, Sam van der
Title: Novel mechanistic insight in cholesteryl ester transfer protein production and pharmacological inhibition
Issue Date: 2017-02-23
Novel mechanistic insight in Cholesteryl Ester Transfer Protein production and pharmacological inhibition
Sam Job Leo Van der Tuin
Nat.Struct.Mol.Biol. 14:106-113'.
Cover design: Sam J.L. van der Tuin and Gildeprint
Printing: Gildeprint, Enschede ISBN: 978-94-6233-533-2
© 2017, Sam J.L. van der Tuin
No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form, by any means, electronic or mechanical, without prior written permission of the copyright owner.
Novel mechanistic insight in Cholesteryl Ester Transfer Protein production and pharmacological inhibition
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 23 februari 2017
klokke 16:15 uur
door
Sam Job Leo van der Tuin
geboren te Tilburg in 1983
Leden promotiecommissie: Prof. dr. J.W. Jukema
Prof. dr. E Lutgens (AMC, Amsterdam) dr. J.M.G. Princen (TNO-Gaubius, Leiden) dr. J.A. Kuivenhoven (UMCG, Groningen)
The work described in this thesis was performed at the department of Medicine, division Endocrinology and the department of Human Genetics at Leiden University Medical Center, Leiden, The Netherlands, and at the Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.
The research described in this thesis was performed within the framework of CTMM, the Center for Translational Molecular Medicine (www.ctmm.nl), project PREDICCt (grant 01C- 104).
TABLE OF CONTENT
Chapter 1. General introduction 7
Chapter 2. Plasma cholesteryl ester transfer protein is predominantly
derived from Kupffer cells 23
Chapter 3. Hepatic expression of cholesteryl ester transfer protein is
confined to F4/80+Ly6C-Clec4f+Vsig4+ macrophages 51
Chapter 4. Lipopolysaccharide increases HDL-cholesterol by reducing
cholesteryl ester transfer protein expression in Kupffer cells 73
Chapter 5. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP
activity and reduction of plasma PCSK9 89
Chapter 6. Discussion 111
Suppl chapter 1. Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion
stability and adds to the beneficial effects of atorvastatin 125
Addendum Summary 153
Samenvatting 157
List of publications 163
Curriculum Vitae 165 Dankwoord 167
