High fat diet induced disturbances of energy metabolism
Berg, S.A.A. van den
Citation
Berg, S. A. A. van den. (2010, October 6). High fat diet induced disturbances of energy metabolism. Retrieved from https://hdl.handle.net/1887/16010
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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High fat diet induced disturbances of energy metabolism
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 6 oktober 2010 klokke 16.15 uur
door
Sjoerd Adrianus Antonius van den Berg
geboren te Roosendaal en Nispen in 1981
Promotiecommissie
Promotor: Prof. Dr. L.M. Havekes Overige leden: Prof. Dr. R.R. Frants
Prof. Dr. J.A. Romijn
Prof. Dr. M.R. Muller (Universiteit van Wageningen) Dr. K. Willems van Dijk
Dr. P. Schrauwen (Universiteit van Maastricht) Dr. P.J. Voshol (Universiteit van Cambridge)
The studies described in this thesis were performed at the department of Human Genetics and in close collaboration with the department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands and were financially
supported by grants from the Nutrigenomics Consortium and The Netherlands Consortium for Systems Biology.
Voor eenieder die mij na staat, maar in het bijzonder
Linda
Colofon
Cover: Tim A.A. van den Berg “Balancing the scales”
Design: TSE Systems Printing: TSE Systems
Publication of this thesis was financially supported by TSE Systems GmbH
© Sjoerd van den Berg Except (parts of)
Chapters 3 (Springer Science and Business Media), 4 (Elsevier) and 6 (Elsevier)
No part of this thesis may be reproduced in any form by print, photocopy, digital file, internet or any other means without written permission of the copyright owner
ISBN number:
Table of contents
Introduction ... 3
Chapter 1, Part A: Biological background of obesity, insulin resistance and dyslipidemia ... 3
Chapter 1, Part B: Practice and principles of indirect calorimetry and hyperinsulinemic-euglycemic clamp analysis... 10
Chapter 2: The hepatic lipid and plasma inflammatory marker profile of APOE3Leiden mice to high fat diets is characterized by a distinctly phased response. ... 15
Chapter 3: High fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance. ... 35
Chapter 4: High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity ... 47
Chapter 5: The iminosugar AMP-DNM reduces body weight by decreasing food intake and increasing fat oxidation in ob/ob mice ... 61
Chapter 6: High levels of whole body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice... 73
Chapter 7: General discussion... 85
Chapter 8: Future perspectives ... 91
References ... 95
Summary ...119
Nederlandse samenvatting...121
Publications...123
Curriculum Vitae ...129
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