Citation
Henneman, P. (2010, April 14). Genetics of metabolic syndrome and related traits.
Retrieved from https://hdl.handle.net/1887/15214
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Genetics of Metabolic Syndrome and related traits
Peter Henneman
genetics of metabolic syndrome and related traits
© 2010 Peter Henneman ISBN: 978-90-9025102-8
except (parts of):
Chapter 2: BMJ Publishing Group Ltd.
Chapter 3 and 8: Elsevier
Chapter 4 and 6: John Wiley & Sons, Inc.
Chapter 5: Nature Publishing Group Chapter 7: American Diabetes Association
Cover & design: Maarten van Maanen Printed by: Gildeprint Drukkerijen
No part of this thesis may be reproduced in any form, by print, photocopy, digital file, internet or any other means without written permission of the copyright owner.
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Genetics of Metabolic Syndrome and related traits
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 17 februari 2010
klokke 13.45 uur door Peter Henneman geboren te Katwijk aan Zee
in 1975
genetics of metabolic syndrome and related traits
Overige leden:
prof. dr. B.A. Oostra (Erasmus MC, Rotterdam) prof. dr. P. de Knijff
prof. dr. J.A. Romijn
prof. dr. L. Groop (Lund University, Sweden)
The studies presented in this thesis were performed at the department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands and at the department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
The studies described in this thesis were financially supported by the Nutrigenomics Consortium (NGC) and by the Centre for Medical Systems Biology (CMSB) in the framework of the Netherlands Genomics Initiative (NGI).
I am grateful to the participants and the general practitioners in the Rucphen region for their contributions to the Erasmus Rucphen Family study.
Publication of this thesis was financially supported by:
Novo Nordisk B.V.
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Voor Jolijn
genetics of metabolic syndrome and related traits
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Contents
Chapter 1
General Introduction
Chapter 2
Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: The Erasmus Rucphen Family (ERF) study
J Med Genet 2008; 45: 572-577
Chapter 3
Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism
Atherosclerosis 2007; 193(1): 129-134
Chapter 4
Estrogen induced hypertriglyceridemia in an apolipoprotein AV deficient patient
J Intern Med 2008; 263(1): 107-108
Chapter 5
The expression of type III hyperlipoproteinemia: involvement of lipolysis genes
Eur J Hum Genet 2008; 17: 620–628
Chapter 6
Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome
J Intern Med 2009
Chapter 7
The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits
Diabetes Care 2010
Chapter 8
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome- wide association analyses including 4659 European individuals
Atherosclerosis 2009
Chapter 9
General Discussion & Future Perspectives
Summary Samenvatting Abbreviations List of Publications Curriculum Vitae
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genetics of metabolic syndrome and related traits
