Diseases of the nervous system associated with calcium channelopathies
Todorov, B.B.
Citation
Todorov, B. B. (2010, June 2). Diseases of the nervous system associated with calcium channelopathies. Retrieved from https://hdl.handle.net/1887/15580
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/15580
Note: To cite this publication please use the final published version (if applicable).
Diseases of the Nervous system
associateD with calcium chaNNelopathies
BoyaN toDorov
Layout and printing by Off Page, www.offpage.nl ISBN: 978-94-90371-13-5
Copyright © 2009 by Boyan Todorov. All rights reserved. Copyright of the individual chapters rests with the author(s), with the following exceptions:
Chapter 2: Elsevier B.V.
Chapter 3: Wiley-Liss Inc.
Chapter 7: American Neurological Association No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 2 juni 2010
klokke 16:15 uur
door
BoyaN BoGDaNov toDorov
geboren te Sofia (Bulgarije) in 1979
Diseases of the Nervous system
associateD with calcium chaNNelopathies
4
promotiecommissie
Promotores: Prof. dr. R. R. Frants Prof. dr. C.I. de Zeeuw1,2
Co-promotor: Dr. A.M.J.M. van den Maagdenberg Overige leden: Prof. dr. M.D. Ferrari
Dr. F.E. Hoebeek2 Prof. dr. J.H. Meijer Prof. dr. G. Smit3
1Royal Dutch Academy for Sciences, Amsterdam
2Erasmus MC, Rotterdam
3Vrije Universiteit, Amsterdam
The majority of studies presented in this thesis were performed at the Center for Human and Clinical Genetics of the Leiden University Medical Center (LUMC), Leiden, and the Department of Neuroscience of the Erasmus Medical Center (EMC), Rotterdam, The Netherlands. This work was supported by grants from the Netherlands Organisation for Scientific Research (NWO) (912-02-085, VICI 918.56.602), the EU Research Network (grant HPRN-CT-2000- 00082), and the EU sixth framework programme “EUROHEAD” (grant LSHM-CT- 2004-504837), and by the Centre for Medical Systems Biology (CMSB) established by the Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research (NGI/NWO).
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Chapter 1 Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9 Addendum
taBle of coNteNts
General introduction 7
Redundancy of Cav2.1 channel accessory subunits in
transmitter release at the mouse neuromuscular junction 31 Brain Res. 2007;1143:92-101
Conditional inactivation of the cacna1a
gene in transgenic mice 49
Genesis. 2006;44:589-94
Ablation of CaV2.1 channels in cerebellar granule cells affects Purkinje cell firing regularity
without causing motor discoordination 59
In preparation
Purkinje cell-specific ablation of CaV2.1 channels
is sufficient to cause cerebellar ataxia in mice 79 Submitted
Generation and characterization of transgenic mice expressing
T666M mutant CaV2.1-α1 subunits in Purkinje cells 91 In preparation
High cortical spreading depression susceptibility
and migraine-associated symptoms in CaV2.1 S218L mice 105 Ann Neurol. 2010;67:85-98
Enhanced granule cell output and irregular Purkinje cell firing
in gain-of-function Cacna1aS218L mutation 131 Submitted
General discussion 159
Summary 179
Samenvatting 183
List of publications 188
Curriculum vitae 189
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