Citation
Buijs, J. T. (2009, January 21). Pathogenesis and treatment of skeletal metastasis : studies in animal models. Retrieved from https://hdl.handle.net/1887/13413
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Pathogenesis and Treatment of Skeletal Metastasis
Studies in animal models
Jeroen T. Buijs
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 21 januari 2009
klokke 15:00 uur
door
Jeroen Theodorus Buijs geboren te Amsterdam
in 1979
Pathogenesis and Treatment of Skeletal Metastasis
Studies in animal models
The studies presented in this thesis were performed at the departments of Endocrinology and Metabolic Diseases, Pathology, and Urology at the Leiden University Medical Center, Leiden, The Netherlands and at the department of Urology, University of Bern, Inselspital, Switzerland.
The research described in this thesis was financially supported by grants from the Dutch Cancer Society (RUL2001- 2485) and the European Sixth Framework programme PRIMA (FP504-587).
The printing of this thesis was financially supported by:
Jurriaanse Stichting
Procter & Gamble Pharmaceuticals Nederland B.V.
Astellas Pharma B.V.
Merck Sharp and Dohme B.V.
Eli Lilly Nederland B.V.
Aan mijn ouders, voor Nurka,
Contents
Chapter 1. General introduction 9
partly published in Cancer Letters, in press.
Chapter 2. Prognostic significance of periodic acid-Schiff-positive 71 patterns in primary breast cancer and its lymph node metastases Breast Cancer Res Treat 2004; 84:117-30.
Chapter 3. Optical imaging of cancer metastasis to bone marrow: 91 a mouse model of minimal residual disease
Am J Pathol 2002; 160:1143-53.
Chapter 4. Interference with the microenvironment supports 109 impairs the de novo formation of bone metastasis in vivo
Cancer Res 2005; 65:7682-90.
Chapter 5. Inhibition of bone resorption and growth of breast cancer 133 in the bone microenvironment
Bone, in press.
Chapter 6. Bone morphogenetic protein 7 in the development and 147 treatment of bone metastases from breast cancer.
Cancer Res 2007; 215:8742-51
Chapter 7. BMP7, a putative regulator of epithelial homeostasis in the human 171 prostate, is a potent inhibitor of prostate cancer bone
metastasis in vivo.
Am J Pathol 2007; 171:1047-57.
Chapter 8. General discussion 195
Chapter 9. Summary – Samenvatting 225
List of abbreviations 235
List of publications 237
Curriculum vitae 239
