Citation
Grauss, R. W. (2008, January 17). Regenerative medicine in cardiovascular disease: from tissue enginering to tissue regeneration. Retrieved from https://hdl.handle.net/1887/12556
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Colophon
The studies described in this thesis were performed at the departments of Antomy and Embryology, and Cardiology of the Leiden University Medical Center, Leiden, the Netherlands.
Copyright © 2008 Robert W. Grauss, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, whitout prior written permission of the author.
Cover After a painting by Mieneke van Teylingen
“Salamanders are the superstars of regeneration. They can grow back not only limbs but also tails, parts of their hearts and the retinas and lenses in their eyes.” New York Times, September 24, 2002
Layout De Boer & van Teylingen, The Hague, the Netherlands Printed by Den Haag Off set, The Hague, the Netherlands ISBN 978-90-9022595-1
R E G E N E R A T I V E M E D I C I N E I N C A R D I O V A S C U L A R D I S E A S E : F R O M T I S S U E E N G I N E E R I N G T O T I S S U E R E G E N E R A T I O N
PROEFSCHRIFT ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnifi cus prof. mr. P. F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 17 januari 2008
klokke 13.45 uur
door
ROBERT WILLEM GR AUSS geboren te Oud Beijerland
in 1977
PROMOTIECOMMISSIE
P R O M O T O R E S PROF. DR. M .J. SCHALIJ
PROF. DR. A .C. GITTENBERGER-DE GROOT
C O - P R O M O T O R E S DR. D.E. ATSMA DR. M .C. DE RUITER
R E F E R E N T PROF. DR. D.J. VAN VELDHUISEN
(UNIVERSITEIT VAN GRONINGEN)
L I D PROF. DR. W.E. FIBBE
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
R E G E N E R A T I V E M E D I C I N E I N C A R D I O V A S C U L A R D I S E A S E : F R O M T I S S U E E N G I N E E R I N G T O T I S S U E R E G E N E R A T I O N
“THIS IS NOT THE END. IT IS NOT EVEN THE BEGINNING OF THE END.
BUT IT IS, PERHAPS, THE END OF THE BEGINNING”
Sir Winston Churchill (1942)
Voor mijn ouders Aan Carolien
TABLE OF CONTENTS
Chapter 1 General introduction and outline of the thesis 9
P A R T I T I S S U E E N G I N E E R I N G O F A O R T I C V A L V E L E A F L E T S 47
Chapter 2 Histological evaluation of decellularised porcine aortic valves:
matrix changes due to diff erent decellularisation methods
Eur J Cardiothorac Surg. 2005;27:566-71 49
Chapter 3 Decellularisation of rat aortic valve allografts reduces leafl et destruction and extracellular matrix remodeling
J Thoracic Cardiovasc Surg 2003;126:2003-10 63 Letter to the editor
J Thoracic Cardiovasc Surg 2004;128:155-56 80
Chapter 4 Decellularization of rat aortic valve allografts reduces the cellular immune response resulting in a structurally intact collagen network irrespective of collagen denaturation
Submitted for publication 83
P A R T I I C E L L B A S E D R E G E N E R A T I V E T H E R A P Y F O R T H E T R E A T M E N T O F
A C U T E M Y O C A R D I A L I N F A R C T I O N 101
Chapter 5 Mesenchymal Stem Cells from Ischemic Heart Disease Patients Improve Left Ventricular Function after Myocardial Infarction
Am J Physiol Heart Circ Physiol 2007;293:H2438-47 103
Chapter 6 Forced Myocardin Expression enhances the therapeutic eff ect of Mesenchymal Stem Cells from Patients with Ischemic Heart Disease in a Mouse Myocardial Infarction Model
Submitted for publication 123
Chapter 7 Preservation of left ventricular function and attenuation of remodelling after transplantation of human epicardium-derived cells into the infarcted mouse heart
Circulation 2007;116:917-27 145
R E G E N E R A T I V E M E D I C I N E I N C A R D I O V A S C U L A R D I S E A S E : F R O M T I S S U E E N G I N E E R I N G T O T I S S U E R E G E N E R A T I O N
P A R T I I I C A R D I A C P H E N O T Y P I N G I N R E G E N E R A T I V E M E D I C I N E : D I F F E R E N T
M E T H O D S F O R T H E M U R I N E H E A R T 177
Chapter 8 Assessment of left ventricular function in the chronic ischemic failing mouse heart by magnetic resonance imaging and conductance catheter: a head to head comparison
Submitted for publication 179
S U M M A R Y , C O N C L U S I O N S A N D F U T U R E P E R S P E C T I V E S 197
S A M E N V A T T I N G , C O N C L U S I E S E N T O E K O M S T P E R S P E C T I E V E N 205
L I S T O F P U B L I C A T I O N S 215
A C K N O W L E D G E M E N T S 220
C U R R I C U L U M V I T A E 223
8
R E G E N E R A T I V E M E D I C I N E I N C A R D I O V A S C U L A R D I S E A S E : F R O M T I S S U E E N G I N E E R I N G T O T I S S U E R E G E N E R A T I O N
