Tuyn, J. van
Citation
Tuyn, J. van. (2008, January 9). Cellular and genetic approaches to myocardial
regeneration. Department of Cardiology and Department of Molecular Cell Biology (MCB), Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University.
Retrieved from https://hdl.handle.net/1887/12548
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Cellular and genetic approaches
to myocardial regeneration
Cover, Design & Layout by John van Tuyn Printed by Gildeprint BV, Enschede
Copyright © 2007 John van Tuyn, Delft, the Netherlands. All rights reserved. No part of this publication may be reproduced or transmitted in any form, without permission from the copyright owner.
Cellular and genetic approaches to myocardial regeneration
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 9 januari 2008 klokke 16.15 uur
door
John van Tuyn
geboren te Den Haag
in 1978
Promotores: Prof. dr. M.J. Schalij Prof. dr. A. van der Laarse Copromotores: Dr. A.A.F. de Vries
Dr. D.E. Atsma
Referent: Prof. dr. Y.M. Pinto
(Academisch Ziekenhuis Maastricht) Overige leden: Prof. dr. R.C. Hoeben
Prof. dr. D.L. Ypey
The research described in this thesis was performed at the departments of Cardiology and Molecular Cell Biology of the Leiden University Medical Center, Leiden, the Netherlands.
The work described in this thesis was supported by the Netherlands Orga-
nization for Health Research and Development (ZonMw; Grant MKG5942)
and the Interuniversity Cardiology Institute of the Netherlands (ICIN).
Chapter 1 General introduction 7
Chapter 2 Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin
Cardiovascular Research 2005;67(2):245-255
27
Appendix Editorial by Carlo Ventura
Cardiovascular Research 2005;67(2):182 – 183
51
Chapter 3 Epicardial cells of human adults can undergo an epithelial- to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro
Stem Cells 2007;25(2):271-278
57
Chapter 4 Fibroblasts from human post-myocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene
The FASEB Journal 2007;21:3369-3379
81
Chapter 5 Resynchronization of separated rat cardiomyocyte fields using genetically modified human ventricular scar fibroblasts
Circulation 2007;116:2018-2028
103
Chapter 6 Forced myocardin expression enhances the therapeutic effect of human mesenchymal stem cells after transplantation in ischemic mouse hearts
Submitted for publication
125
Chapter 7 Gene expression profiling of myocardin-induced cardiomyogenic differentiation in human cardiac progenitor cells
Under preparation
149
Chapter 8 Summary, conclusions and future directions Samenvatting, conclusies en vervolgonderzoek
177 185
List of publications 193
Curriculum Vitae 201
