Cellular and genetic approaches to myocardial regeneration Tuyn, J. van

To determine the extent to which myocardin induces the differentiation of hMSCs and hDFs into cardiac, skeletal, or smooth muscle cells, we analyzed the expression of marker genes

Forced myocardin expression primes cardiac and smooth muscle transcription patterning in human mesenchymal stem

Chapter 3 Epicardial cells of human adults can undergo an epithelial-to-mesench ymal tr ansition and obtain char acteristics of smooth muscl e cells in vitro..

Key findings of this study are (i) myocL gene transfer leads to the induction of a (partial) cardiac phenotype in hVSFs from adult patients by activating genes encoding among

Methods and Results: An in vitro model was used to study the effects of forced expression of the myocardin (MYOCD) gene in human ventricular scar fibroblasts (hVSFs)

Key findings of this study are: (1) Injection of hMSC and hMSC MYOCD into infarcted myocardium results in a relatively preserved LV function compared to injection of medium alone;

In this study we compared the gene expression programs induced by the main cardiac and smooth muscle isoforms of myocardin, to investigate their contribution to the differential

Altogether, these results demonstrate that the phenotypic changes induced by forced expression of myocardin in MSCs allow these cells to improve cardiac function to a greater