The role of apolipoprotein CI in lipid metabolism and
bacterial sepsis
Berbée, J.F.P.
Citation
Berbée, J. F. P. (2007, May 24). The role of apolipoprotein CI in lipid metabolism and bacterial sepsis. Retrieved from
https://hdl.handle.net/1887/11973
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/11973
Note: To cite this publication please use the final published version (if applicable).
Role of Apolipoprotein CI in Lipid Metabolism
and Bacterial Sepsis
Role of Apolipoprotein CI in Lipid Metabolism
and Bacterial Sepsis
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 24 mei 2007
klokke 13.45 uur
door
Jimmy Fransiscus Paulus Berbée geboren te Leiden
in 1977
Promotiecommissie
Promotor: Prof. dr. ir. L.M. Havekes Co-Promotor: Dr. P.C.N. Rensen
Referent: Dr. E.S.G. Stroes (AMC, Amsterdam) Overige leden: Prof. dr. J.A. Romijn
Prof. dr. R.G.J. Westendorp
Dr. H.E. de Vries (VUMC, Amsterdam)
The studies presented in this thesis were performed at the Gaubius Laboratory of TNO-Quality of Life and the department of Endocrinology and Metabolic Diseases at the Leiden University Medical Center, Leiden, The Netherlands.
The research was financially supported by a grant from the Netherlands Organization of Scientific Research-Research Institute of Diseases in the Elderly (NWO-RIDE Grant 014-90-001).
The printing of this thesis was financially supported by:
TNO-Quality of Life, business unit Biosciences, Leiden Dutch Atherosclerosis Society
Boehringer-Ingelheim BV Schering-Plough BV Merck Sharp & Dohme BV
Cover design: Jimmy Berbée
Printing: Ponsen & Looijen bv, Wageningen, The Netherlands ISBN: 978-90-6464-130-5
Berbée, Jimmy
Role of Apolipoprotein CI in Lipid Metabolism and Bacterial Sepsis Proefschrift Leiden
Met literatuuropgave – Met samenvatting in het Nederlands
© 2007, Jimmy Berbée, Leiden, The Netherlands
No part of this thesis may be reproduced or transmitted in any form or by any means, without written permission from the author.
Contents
Chapter 1 General Introduction
Partly published in J Endotoxin Research 2005
Chapter 2 Severe Hypertriglyceridemia in Human APOC1 Transgenic Mice is Caused by Apolipoprotein CI-induced Inhibition of LPL
J Lipid Research 2005
Chapter 3 Apolipoprotein CI Directly Inhibits LPL Activity Independent of the VLDL Receptor and Apolipoprotein CIII in Mice
Biochim Biophys Acta 2006
Chapter 4 Apolipoprotein E Plasma Levels and Risk of Cardiovascular Mortality in Old Age
PLoS Medicine 2006
Chapter 5 Apolipoprotein CI Stimulates the Inflammatory Response to Lipopolysaccharide and Reduces Mortality in Gram- negative Sepsis
FASEB J 2006
Chapter 6 Apolipoprotein CI Modulates the Biological Response to Lipopolysaccharide: Analysis of the Structure and Function Relationship
Manuscript in preparation
Chapter 7 Plasma Apolipoprotein CI Correlates with Increased Survival in Patients with Severe Sepsis
Submitted for publication
Chapter 8 Plasma apolipoprotein CI Protects Against Mortality from Infection in Old Age
Submitted for publication
Chapter 9 General Discussion Chapter 10 Summary/Samenvatting Chapter 11 List of Abbreviations
List of Publications Curriculum Vitae
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173 189 201 204 209
