Modulation of genes involved in inflammation and cell death in
atherosclerosis-susceptible mice
Zadelaar, Anna Susanne Maria
Citation
Zadelaar, A. S. M. (2006, March 23). Modulation of genes involved in inflammation and cell death in atherosclerosis-susceptible mice. Retrieved from https://hdl.handle.net/1887/4401
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4401
Modulation of Genes Involved in Inflammation and
Cell Death in Atherosclerosis-Susceptible Mice
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties
te verdedigen op donderdag 23 maart 2006 klokke 14.15 uur
door
Anna Susanne Maria Zadelaar
Promotiecommissie
Promotor: Prof. dr. ir. L.M. Havekes Co-Promotor: Dr. B.J.M. van Vlijmen Referent: Prof. dr. Th.J. van Berkel Overige leden: Prof. dr. R.E. Poelmann
Prof. dr. J.W. Jukema
Dr. J.C. Marine (University of Ghent, Ghent, Belgium)
The studies presented in this thesis were performed at the Gaubius Laboratory of TNO-Quality of Life, Leiden, the department of Immunology at the Erasmus University, Rotterdam and the Laboratory for Molecular Cancer Biology of the University of Ghent, Ghent, Belgium.
The research was financially supported by a grant from the Netherlands Organization of Scientific Research (NWO/ ZonMW #902-26-242).
The printing of this thesis was financially supported by: TNO-Quality of Life, The Gaubius Laboratory
Netherlands Organization of Scientific Research (NWO/ ZonMW) Astra Zeneca, Sweden
What’s done is done.
Cover: Gare St. Lazare, Paris, France
Copyright: PhotoLogiX.nl, by Bruno van den Elshout
Printing: Ponsen en Looijen, Wageningen, The Netherlands ISBN: 90 6464 491 8
Zadelaar, Susanne
Modulation of Genes Involved in Inflammation and Cell Death in Atherosclerosis-Susceptible Mice
Proefschrift Leiden.
Met literatuuropgave − Met samenvatting in het Nederlands
© Susanne Zadelaar, 2005
Contents
Chapter 1: General Introduction
Chapter 2: Tumor Necrosis Factor-α Promotes Atherosclerotic Lesion Progression In APOE*3-Leiden Transgenic Mice
Cardiovasc Res 2005; 66(1): 179-85
Chapter 3: Increased Vulnerability of Pre-existing Atherosclerosis in ApoE
Deficient Mice Following Adenovirus-mediated Fas Ligand Gene Transfer
Atherosclerosis 2005; 183(2): 244-50
Chapter 4: Mdm2 Protects Terminally Differentiated Smooth Muscle Cells
from p53-Mediated Cell Death with a Necrotic Morphotype
Submitted
Chapter 5: Local Cre-mediated Gene Recombination in Vascular Smooth
Muscle Cells in Mice
Transgenic Research 2005; In press
Chapter 6: The Dual PPARα/γ Agonist Tesaglitazar Reduces Atherosclerosis Development Beyond its Plasma Cholesterol-Lowering Effects in APOE*3Leiden Transgenic Mice
Submitted
Chapter 7: General Discussion
