Inflammation in injury-induced vascular remodelling : functional involvement and therapeutical options
Schepers, A.
Citation
Schepers, A. (2008, April 9). Inflammation in injury-induced vascular remodelling : functional involvement and therapeutical options. TNO Quality of Life, Gaubius Laboratory, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University. Retrieved from https://hdl.handle.net/1887/12687
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INFLAMMATION IN INJURY-INDUCED VASCULAR REMODELING;
Functional Involvement and
Therapeutical Options
Cover: Thickenend vein graft 2008, A.Schepers
ISBN 978-90-9022822-8 Layout by Claire Monaghan Printed by Gildeprint, Enschede
The printing of this thesis was financially supported by Arie Blok Diervoeding, Mutaro Management and TNO Quality of Life
Inflammation in injury-induced vascular remodeling;
functional involvement and therapeutical options
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de rector Magnificus prof. mr. P.F. van der Heijden,
volgens het besluit van het Colleges voor Promoties te verdedigen op woensdag 9 april 2008
klokke 16.15 uur door
Abbey Schepers
geboren te Delft in 1976
Promotiecommissie:
Promotores: Prof. Dr. P.H.A. Quax Prof. Dr. J.H. van Bockel Referent: Prof. Dr. A.J. van Zonneveld Overige Leden: Prof. Dr. V.W. van Hinsberg
Prof. Dr. M.R. Daha Prof. Dr. T.J.C. van Berkel
The research described in this thesis was performed in the Gaubius Laboratory, TNO-Quality of Life, Leiden, The Netherlands.
The studies described in this thesis was supported by a grant of The Netherlands Heart Foundation (Molecular Cardiology Program, Grant M93.001).
Aan mijn ouders Voor Ries, Fynn en Jory
CONTENTS
CHAPTER 1
General Introduction 9
CHAPTER 2
Histopathologic Alterations Following Local Delivery of Dexamethasone to Inhibit
Restenosis in Murine Arteries. 35
CHAPTER 3
The effect of interleukin-10 knock-out and overexpression on neointima formation in
hypercholesterolemic ApoE3Leiden mice. 53
CHAPTER 4
Short-term dexamethasone treatment inhibits vein graft thickening in
hypercholesterolemic ApoE3Leiden transgenic mice. 71
CHAPTER 5
Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation
and attenuates vein graft thickening both in vitro and in vivo. 89 CHAPTER 6
Both MIP-1α and RANTES and their receptors are expressed in murine vein grafts
and aggravate vein graft remodeling. 107
CHAPTER 7
Inhibition of Complement Component C3 Reduces Vein Graft Atherosclerosis in
ApoE3Leiden Transgenic Mice. 125
CHAPTER 8
Blocking of the Chemotactic Complement Endproduct C5a Inhibits Accelerated
Atherosclerosis in Vein Grafts. 143
CHAPTER 9
Discussion 159
NEDERLANDSE SAMENVATTING 169
LIST OF PUBLICATIONS 179
CURRICULUM VITAE 181
COLOUR FIGURE OVERVIEW 183
