Studies on the pathophysiological aspects of the metabolic syndrome in transgenic mice
Hu, L.
Citation
Hu, L. (2009, February 25). Studies on the pathophysiological aspects of the metabolic syndrome in transgenic mice. Retrieved from https://hdl.handle.net/1887/13520
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Studies on the Pathophysiological Aspects of
the Metabolic Syndrome in Transgenic Mice
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden op gezag van Rector Magnificus prof. mr. P.F. van der Heijden
volgens besluit van het College voor Promoties te verdedigen op woensdag 25 februari 2009
klokke 13:45 uur
door
Lihui Hu
geboren te Yu Hu, Zhejiang Province (China) in 1976
Studies on the Pathophysiological Aspects of the Metabolic Syndrome
in Transgenic Mice
Promotiecommissie
Promotor: Prof. dr. ir. L.M. Havekes Co-promotores: Dr. J.T. Tamsma
Dr. B.J.M. van Vlijmen
Referent: Dr. F.L.J. Visseren (UMC Utrecht) Overige leden: Prof. dr. J.A. Romijn
Prof. dr. Th.J. van Berkel
The studies presented in this thesis were performed at the Gaubius Laboratory of TNO-Quality of Life and the department of General Internal Medicine/Endocrinology and Metabolic Diseases at the Leiden University Medical Center, Leiden, The Netherlands.
The research was partly financially supported by a grand from The Netherlands Organisation of Scientific Research Mosaic (NWO 017.003.083).
Financial support by The Netherlands Heart Foundation and J.E. Juriaanse Stichting for the publication of this thesis is gratefully acknowledged.
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䔈㷳䖽全㒠䤓䓅㹜
Cover photo: Urban Display Cover design: Textcetera Lay-out: Textcetera
Printing:
The printing of this thesis was financially supported by:
Institute for cardiovascular research VUMC and Leiden Vascular Medicine International Atherosclerosis Society GlaxoSmithKline
Arie Blok Diervoeding Menarini Farma Nederland
AstraZeneca B.V. Merck Sharp & Dohme
Boehringer Ingelheim NovoNordisk
Eli Lilly Nederland B.V. Schering-Plough B.V.
Genzyme Nederland Zambom
ISBN: 978 90 79969 02 9 NUR: 871
Lihui Hu
Studies on the Pathophysiological Aspects of the Metabolic Syndrome in Transgenic Mice Proefschrift Leiden
Met literatuuropgave – Met samenvatting in het Nederlands
© 2009, Lihui Hu, Leiden, The Netherlands
No part of this thesis may be reproduced or transmitted in any form of by any means, without written permission from the author
Ipskamp Drukkers B.V.
Contents
Chapter 1 General Introduction 9
Chapter 2 The clearance of plasma PAI-1 is not affected in insulin
resistant mice 31
Submitted
Chapter 3 Plasma PAI-1 level is not regulated by the hepatic low-density
lipoprotein receptor-related protein 43
J. Throm Haemost (2007) 11:2301-4
Chapter 4 The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans
and SR-BI 53
J. Lipid Res (2008) 49:1553-61
Chapter 5 Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double
knockout mice. 75
Arterioscler Thromb Vasc Biol (2006) 26:2710-5
Chapter 6 Decreased circulating endothelial progenitor cell counts accompany elevated CRP levels in subjects with the metabolic syndrome without overt cardiovascular disease 89 In preparation
Chapter 7 General discussion 103
Chapter 8 Summery/Samenvatting 113
List of Abbreviations 119
List of Publications 121
Curriculum Vitae 123
