Air travel and venous thrombosis. Results of the WRIGHT study. Part II: Mechanism Schreijer, A.J.M.

Citation

Schreijer, A. J. M. (2009, September 24). Air travel and venous thrombosis. Results of the WRIGHT study. Part II: Mechanism. Retrieved from

https://hdl.handle.net/1887/14028

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14028

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Air travel and venous thrombosis

Results of the WRIGHT study Part II: Mechanism

Anja Johanna Maria Schreijer

Pictures on page 140: Stefan Heijdendael, WRIGHT flight, May 24 2004

ISBN/EAN: 978-94-90122-50-8

© Copyright 2009 Anja Schreijer

No part of this book may be reproduced, stored in a retrieval system or transmitted in any form of by any means, without the written permission of the author or, when appropriate, of the publishers of publications.

Financial support for the publication of this thesis was kindly provided by the Arbo Advies, Medical Market, Stich- ting Prof. Dr. J. Jongbloedfonds, Federatie van Nederlandse Trombosediensten, de AMSTOL stichting, de stichting tot steun promovendi vasculaire geneeskunde, de Jurriaanse stichting, Astra Zeneca, Boehringer Ingelheim BV, Glaxo Smith Kline BV, Leo Pharma BV en Sanquin.

The (WH and

The

Layo Cove

Air travel and venous thrombosis

Results of the WRIGHT study Part II: Mechanism

Proefschrift

Ter verkrijging van de graad van Doctor aan de Universiteit Leiden,

op gezag van de

Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op donderdag 24 september 2009

klokke 16:15 uur

Anja Johanna Maria Schreijer

geboren te Ambt-Delden in 1976

Prof. Dr P.H. Reitsma

The work described in this thesis was performed at the department of Clinical Epidemiology at the Leiden University Medical Center in Leiden, the Netherlands and at the department of Vascular Medicine at the Academic Medical Center in Amsterdam, the Netherlands. The research was done in the framework of the WRIGHT initiative (WHO Research Into Global Hazards of Travel), and was sponsored by the UK Government and the European Commission.

A part of the research was also supported by a grant from the Leducq Foundation, Paris, France for the development of Transatlantic Networks of Excellence in Cardiovascular Research.

Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.

Table of Contents

Chapter 1. General Introduction and Outline of the Thesis 7 Chapter 2. Travel and Venous Thrombosis: a systematic review 13

Chapter 3. Activation of coagulation system during air travel:

a crossover study 39

Chapter 4. Fluid loss does not explain coagulation activation

during air travel 57 Chapter 5. The effect of air travel on platelets and the vessel wall 73 Chapter 6. Explanations for coagulation activation after air travel 87

Chapter 7. The effect of flight-related behaviour on the risk of

venous thrombosis after air travel 103

Chapter 8. Mechanical prophylaxis for travellers’ thrombosis:

a comparison of three interventions that promote venous outflow 115

Summary and Discussion 121

Samenvatting en Discussie 131

Dankwoord 137