Air travel and venous thrombosis. Results of the WRIGHT study. Part II: Mechanism
Schreijer, A.J.M.
Citation
Schreijer, A. J. M. (2009, September 24). Air travel and venous thrombosis. Results of the WRIGHT study. Part II: Mechanism. Retrieved from
https://hdl.handle.net/1887/14028
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/14028
Note: To cite this publication please use the final published version (if applicable).
Chapter 1
General introduction and
outline of the thesis
Table of Contents
Chapter 1. General Introduction and Outline of the Thesis 7 Chapter 2. Travel and Venous Thrombosis: a systematic review 13
Chapter 3. Activation of coagulation system during air travel:
a crossover study 39
Chapter 4. Fluid loss does not explain coagulation activation
during air travel 57 Chapter 5. The effect of air travel on platelets and the vessel wall 73 Chapter 6. Explanations for coagulation activation after air travel 87
Chapter 7. The effect of flight-related behaviour on the risk of
venous thrombosis after air travel 103
Chapter 8. Mechanical prophylaxis for travellers’ thrombosis:
a comparison of three interventions that promote venous outflow 115
Summary and Discussion 121
Samenvatting en Discussie 131
Dankwoord 137
Promotiecommissie
Promotores: Prof F. R. Rosendaal
Prof H.R. Büller, Academisch Medisch Centrum Amsterdam Copromotores: Dr S.C. Cannegieter
Referent: Prof. Dr M. Greaves, University of Aberdeen Overige leden: Dr S. Middeldorp
Prof. Dr P.H. Reitsma
The work described in this thesis was performed at the department of Clinical Epidemiology at the Leiden University Medical Center in Leiden, the Netherlands and at the department of Vascular Medicine at the Academic Medical Center in Amsterdam, the Netherlands. The research was done in the framework of the WRIGHT initiative (WHO Research Into Global Hazards of Travel), and was sponsored by the UK Government and the European Commission.
A part of the research was also supported by a grant from the Leducq Foundation, Paris, France for the development of Transatlantic Networks of Excellence in Cardiovascular Research.
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The (WH and
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Layo Cove
Air travel and venous thrombosis
Results of the WRIGHT study Part II: Mechanism
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden,
op gezag van de
Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op donderdag 24 september 2009
klokke 16:15 uur
Anja Johanna Maria Schreijer
geboren te Ambt-Delden in 1976
Colofon
Author: Anja Schreijer
Front cover: Olffies Design; Olga van Olffen-Duijn Layout: Olffies Design; Olga van Olffen-Duijn Drukkerij: Gildeprint, Enschede
Pictures on page 140: Stefan Heijdendael, WRIGHT flight, May 24 2004
ISBN/EAN: 978-94-90122-50-8
© Copyright 2009 Anja Schreijer
No part of this book may be reproduced, stored in a retrieval system or transmitted in any form of by any means, without the written permission of the author or, when appropriate, of the publishers of publications.
Financial support for the publication of this thesis was kindly provided by the Arbo Advies, Medical Market, Stich- ting Prof. Dr. J. Jongbloedfonds, Federatie van Nederlandse Trombosediensten, de AMSTOL stichting, de stichting tot steun promovendi vasculaire geneeskunde, de Jurriaanse stichting, Astra Zeneca, Boehringer Ingelheim BV, Glaxo Smith Kline BV, Leo Pharma BV en Sanquin.