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Air travel and venous thrombosis : results of the WRIGHT study : Part I: Epidemiology Kuipers, S.

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Citation

Kuipers, S. (2009, September 24). Air travel and venous thrombosis : results of the WRIGHT study : Part I: Epidemiology. Retrieved from https://hdl.handle.net/1887/14014

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14014

Note: To cite this publication please use the final published version (if applicable).

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Air travel and venous thrombosis

Results of the WRIGHT study Part I: Epidemiology

Saskia Kuipers

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ISBN/EAN: 978-94-90122-49-2

© Copyright 2009 Saskia Kuipers

No part of this book may be reproduced, stored in a retrievel system or transmitted in any form of by any means, without the written permission of the autor or, when appropriate, of the publishers of publications.

Financial support for the publication of this thesis was kindly provided by the Federatie van Nederlandse Trombosediensten, de AMSTOL stichting, de stichting tot steun promovendi vasculaire geneeskunde, de Jurri- aanse Stichting, Jongbloed Fonds, Astra Zeneca, Bayer BV, Boehringer Ingelheim BV, Glaxo Smith Kline BV, Kordia Life Sciences, Pfizer BV and Sanquin.

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Air travel and venous thrombosis

Results of the WRIGHT study Part I: Epidemiology

Proefschrift

Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op donderdag 24 september 2009

klokke 15.00 uur

door

Saskia Kuipers

geboren te Amersfoort in 1978

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Overig lid: Prof. J.P. Vandenbroucke

The work described in this thesis was performed at the department of Clinical Epidemiology at the Leiden University Medical Center in Leiden, the Netherlands and at the department of Vascular Medicine at the Academic Medical Center in Amsterdam, the Netherlands.

Part of the research described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF-2002B53). Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.

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Table of Contents

Chapter 1. Introduction 7

Chapter 2. Travel and venous thrombosis: a systematic review 13

Chapter 3. Use of preventive measures for air travel-related venous

thrombosis in professionals who attend medical conferences 39

Chapter 4. The Absolute Risk of Venous Thrombosis after Air Travel:

a Study of 8 755 Employees of International Organisations 55

Chapter 5. The Risk of Venous Thrombosis after Air Travel:

the contribution of clinical risk factors 69

Chapter 6. The Effect of Elevated Levels of Coagulation Factors on

the Risk of Venous Thrombosis in Long Distance Travellers 79

Chapter 7. The incidence of venous thrombosis in commercial

airline pilots: a cohort study of 2630 pilots 93

Chapter 8. Summary 105

Chapter 9. Samenvatting 111

Dankwoord 116

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