The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/67913
Author: Elffers, T.W.
Title: Obesity and Cardiovascular disease. Results from the Netherlands Epidemiology
of Obesity Study
OBESITY AND CARDIOVASCULAR DISEASE
Results from the Netherlands Epidemiology of Obesity Study
OBESITY AND CARDIOVASCULAR DISEASE
Results from the Netherlands Epidemiology of Obesity Study
Proefschrift
Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 9 januari 2019
Klokke 16.15 uur Door
Theodora (Dorine) Willemine Elffers Geboren te Haarlem
Dr. R. de Mutsert
Prof. dr. P.W. Macfarlane (University of Glasgow) Prof. dr. R.J.G. Peters (AMC-UvA, Amsterdam) Dr. S.J. Pinto-Sietsma (AMC-UvA, Amsterdam)
TW Elffers was supported by a grant of the Board of Directors of the Leiden University Medical Center. Financial support from the Netherlands Association for the Study of Obesity (NASO) is greatly acknowledged. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. The research described in this thesis was supported by a grant of the Dutch Heart Foundation (CVON2014-02 ENERGISE).
The work described in this thesis was performed at the Department of Cardiology and the Department of Clinical Epidemiology of the Leiden University Medical Center, the Netherlands.
TABLE OF CONTENTS
Chapter 1 Introduction 7
Chapter 2 Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women.
21
Chapter 3 Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease
37
Chapter 4 Relation of Overall and Abdominal Adiposity with
Electrocardiogram Parameters of Subclinical Cardiovascular Disease in Individuals Aged 45 to 65 Years (From the Netherlands Epidemiology of Obesity Study)
55
Chapter 5 Borderline Q-waves in individuals without overt
cardiovascular disease: relations with adiposity, subclinical atherosclerosis and vascular stiffness
75
Chapter 6 Carotid intima media thickness, pulse wave velocity and the spatial QRS-T angle
93
Chapter 7 Improvement of electrocardiographic detection of left ventricular hypertrophy by body mass index and spatial QRS-T angle
107
Chapter 8 General discussion 125
Appendices Nederlandse samenvatting (Summary in Dutch) 138
Dankwoord (Acknowledgements) 143
Curriculum Vitae 144
