Cover Page
The handle
http://hdl.handle.net/1887/85450
holds various files of this Leiden University
dissertation.
Author: Marijt, K.A.
Therapeutic targeting of
immune escaped cancers
The research described in this thesis was performed at the department of medical oncology at the Leiden University Medical Center, the Netherlands. The work discribed in this thesis was funded by a grant of the Dutch Cancer Society (UL 2013-6142)
ISBN: 978-94-028-1919-9 Layout: Koen Marijt Cover design: Koen Marijt Thesis printing: Ipskamp printing
All rights reserved. Nothing from this thesis may be reproduced in any form without permission from the author.
Therapeutic targeting of
immune escaped cancers
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op
dinsdag 18 februari 2020 klokke 16:15 uur
door
Promotor:
Prof. Dr. Sjoerd van der Burg
Co-promotor:
Dr. Thorbald van Hall
Leden promotiecomissie:
Prof. Dr. Jacques (Sjaak) Neefjes (LUMC, Leiden, Nederland)
Table of contents:
CHAPTER 1
General introduction
CHAPTER 2
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy
CHAPTER 3
Metabolic stress in cancer cells induces immune escape through an IFN-γ signaling blockade via PI3K pathway
CHAPTER 4
TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class Ilow cancers
CHAPTER 5
Identification of non-mutated neoantigens presented by TAP-defi-cient tumors
CHAPTER 6
Dendritic cell vaccination therapy for immune escaped cancers
CHAPTER 7
TEIPP peptides: exploration of unTAPped cancer antigens
