Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/67420
Author: Ma, W.
Title: Mechanisms underlying the resistance of human papillomavirusinfected or -transformed cells to Th1 immunity
Mechanisms underlying the resistance of
Human papillomavirusinfected or
-transformed cells to Th1 immunity
4
Mechanisms underlying the resistance of Human papillomavirus-infected or -transformed cells to Th1 immunity
Author: Wenbo Ma
Cover lay out: Idea is provide by Wenbo Ma, cover is desighed by Remco Wetzels. Remcowetzels.nl
Thesis printing: Ridderprint BV, The Netherlands www.ridderprint.nl
Mechanisms underlying the resistance of Human
papillomavirus-infected or -transformed cells to Th1
immunity
PROEFSCHRIFT
ter verkrijging vande graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. Mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 18 december 2018
klokke 15:00 uur
door
Wenbo Ma
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Promotoren: Prof. Dr. S.H. van der Burg
Dr. T. van Hall
Promotiecommissie:
Prof. Dr. C.J.J.M. Stolker
Prof. Dr. P. ten Dijke LUMC
Mw. Dr. R.D.M. Steenbergen VUMC, Amsterdam Prof. Dr. E. Wiertz UMC, Utrecht
Mw. Prof. Dr. M. Jager LUMC Prof. Dr. P.P.G. van Benthem LUMC
Table of contents
Chapter 1 Introduction 1
Chapter 2 Human papillomavirus (HPV) downregulates the expression of IFITM1 and RIPK3 to escape from IFNγ and TNFα
mediated anti-proliferative effects and necroptosis 45
Chapter 3 Control of immune escaped human papilloma virus is
regained after therapeutic vaccination 89
Chapter 4 Intratumoral HPV16-specific T cells constitute a highly active tumor microenvironment in HPV16-driven oropharyngeal cancer 109
Chapter 5 EGFR signaling suppresses type 1 cytokine-induced
T-cell attracting chemokine secretion in head and neck cancer 151
