Citation
Mooyaart, A. L. (2011, January 27). Diabetic nephropathy : pathology, genetics and carnosine metabolism. Retrieved from
https://hdl.handle.net/1887/16393
Version: Corrected Publisher’s Version License:
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Diabetic nephropathy
Pathology, genetics and carnosine metabolism
Antien Mooyaart
system, or transmitted in any form or by any means without permission of the author and corresponding journal.
Lay-out and printing: Gildeprint Drukkerijen – Enschede, the Netherlands Cover figure by: Rebecca van den Heuvel
ISBN: 978-94-6108-120-9
Diabetic nephropathy
Pathology, genetics and carnosine metabolism
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 27 januari 2011
klokke 15.00 uur door
Antien Leonora Mooyaart
geboren te Gouda in 1986
Overige leden:
Prof. dr B.A. Yard
Medizinische Universitätsklinik, Klinikum Mannheim, University of Heidelberg Prof. dr A.J. Rabelink
Prof. dr F.W. Dekker
The studies described in this thesis were performed at the Department of Pathology (Head: Prof. dr G.J. Fleuren), Leiden University Medical Center, Leiden, The Netherlands.
The printing of this thesis was financially supported by:
Novo Nordisk B.V., Sanofi-Aventis Nederland B.V., Pfizer B.V., Roche Nederland B.V., Nutricia Advanced Medical Nutrition, Baxter B.V., Diabetes Fonds, AstraZeneca B.V., MSD B.V., Novartis Pharma.
Aan mijn oma, dr Joke Frets
c
ontentsChapter 1 – General introduction 9
Chapter 2 – Pathologic classification of diabetic nephropathy 41 Chapter 3 – Genetic associations in diabetic nephropathy: a meta-analysis 61
Chapter 4 – Lower frequency of the 5/5 homozygous CNDP1 genotype in 81 South Asian Surinamese
Chapter 5 – Association between CNDP1 genotype and diabetic nephropathy 99 is sex specific
Chapter 6 – CNDP1 polymorphism predisposes for progression to end stage 113 renal disease after glomerular damage
Chapter 7 – Vegetarianism, female gender and increasing age, but not 129 CNDP1 genotype, are associated with reduced muscle carnosine
levels in humans
Chapter 8 – Summary and Discussion 151
Chapter 9 – Nederlandse samenvatting 165
Appendix A – Online supplements 173
Appendix B – List of abbreviations 207
Appendix C – Curriculum Vitae 211
Appendix D – Dankwoord 215
Appendix E – List of publications 219
