Genetic and molecular markers of proteinuria and glomerulosclerosis
IJpelaar, D.H.T.
Citation
IJpelaar, D. H. T. (2009, September 16). Genetic and molecular markers of proteinuria and glomerulosclerosis. Retrieved from
https://hdl.handle.net/1887/13997
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Genetic and molecular markers of
proteinuria and glomerulosclerosis
Daphne H.T. IJpelaar
Genetic and molecular markers of proteinuria and glomerulosclerosis
© D.H.T. IJpelaar, 2009, Leiden, The Netherlands
No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior written permission of the authors
Printed by Gildeprint B.V., Enschede, The Netherlands
Cover was inspired by the sculpture “Berlin”, in Berlin, Germany ISBN: 978-90-9024496-9
Genetic and molecular markers of
proteinuria and glomerulosclerosis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 16 september 2009 klokke 16.15 uur
door
Daphne Hubertina Thea IJpelaar
geboren te Heerlen
in 1979
Promotiecommissie:
Promotor: Prof. Dr. J.A. Bruijn
Co-promotor: Dr. E. de Heer
Overige leden: Prof. Dr. S. Florquin
Academisch Medisch Centrum Universiteit Amsterdam Prof. Dr. A.J. Rabelink
Dr. D.J.M. Peters
The studies described in this thesis were performed at the Department of Pathology (Head: Prof. Dr. G.J. Fleuren), Leiden University Medical Center, Leiden, The Netherlands.
The printing of this thesis was financially supported by:
Matty Brand Stichting J.E. Jurriaanse Stichting
Contents
General introduction
Chapter 1 7
The use of extracellular matrix (ECM) probes and ECM- Chapter 2
related probes for assessing diagnosis and prognosis in renal
diseases 41
The genetic predisposition for glomerulonephritis-induced Chapter 3
glomerulosclerosis in rats is linked to chromosome 1 57 Resistance to proteinuria development in anti-Thy-1 glome-
Chapter 4
rulonephritis is governed by both renal and bone marrow-
derived factors 81
Glomerular hypertrophy precedes albuminuria and segmen- Chapter 5
tal loss of podoplanin in podocytes in Munich Wistar Fröm-
ter rats 99
Fidelity and evolution of recurrent FSGS in renal allografts 12
Chapter 6 3
Summary and general discussion 13
Chapter 7 7
Nederlandse samenvatting 15
Chapter 8 3
Curriculum Vitae 16
Appendix A 1
Abbreviations 16
Appendix B 3
List of publications 16
Appendix C 5
Colour figures 16
Appendix D 9
