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Recirculatory modeling in man using Indocyanine green

Reekers, M.

Citation

Reekers, M. (2012, January 19). Recirculatory modeling in man using Indocyanine green.

Retrieved from https://hdl.handle.net/1887/18390

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/18390

Note: To cite this publication please use the final published version (if applicable).

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Recirculatory Modeling in Man using Indocyanine Green

Marije Reekers

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The studies described in this thesis were performed at the Department of Anesthesiology of the Leiden University Medical Center, Leiden, The Netherlands.

Cover photo by Chris Goodroe Cover design by Jan Ketting Layout by Ad Vletter

Printed by Mostert & van Onderen, Leiden ISBN: 978-90-9026477-6

Copyright: © 2011, M.Reekers, Leiden, The Netherlands.

Exceptions: Chapter 2: © 2003, Kluwer

Chapter 3 and 4: © 2009 and 2010, Lippincott, Williams & Wilkins Chapter 5: © 2011, Springer Verlag

All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without prior written permission by the author.

The printing of this thesis was financially supported by the Department of

Anesthesiology of the Leiden University Medical Center, Leiden, The

Netherlands

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Recirculatory Modeling in Man using Indocyanine Green

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op donderdag 19 januari 2012 klokke 16:15 uur

door

Marije Reekers geboren te Oegstgeest

in 1971

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Promotiecommissie:

Promotor: Prof. dr. A. Dahan

Co-promotores: Dr. F. Boer

Dr. J. Vuyk

Overige leden: Prof. dr. L.P.H.J. Aarts

Prof. dr. M. Weiss, Martin Luther University Halle- Wittenberg, Halle (Saale), Germany

Prof. dr. C.A.J. Knibbe

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The unknown

As we know,

There are known knowns.

There are things we know we know.

We also know

There are known unknowns.

That is to say

We know there are some things We do not know.

But there are also unknown unknowns, The one's we don't know

We don't know.

February 12, 2002

Department of defense news briefing.

Donald Rumsfeld, minister of defense, USA

Aan mijn ouders Joke en Paul Voor Paul, Birgit en Floris

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Contents

Chapter 1 Introduction and Outline of the Thesis 9

Chapter 2 Basic Concepts of Recirculatory Pharmacokinetic Modeling

13

Chapter 3 Cardiovascular Monitoring by Pulse Dye Densitometry or Arterial Indocyanine Green Dilution

25

Chapter 4 Pulse Dye Densitometry and Indocyanine Green Plasma Disappearance in ASA Physical Status I-II Patients

41

Chapter 5 Circulatory Model of Vascular and Interstitial Distribution Kinetics of Rocuronium: a Population Analysis in Patients

57

Chapter 6 Early Phase Pharmacokinetics of Propofol in Humans: the Role of the Lung Explored by Recirculatory Modeling

75

Chapter 7 Recirculatory Pharmacokinetic-Pharmacodynamic Modeling of Propofol in Man

95

Chapter 8 Summary, Conclusions and Future Perspectives 113

Chapter 9 Samenvatting, Conclusies en Toekomstperspectieven 119

Curriculum Vitae 125

List of Publications 127

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