Cover Page
The handle http://hdl.handle.net/1887/48287 holds various files of this Leiden University dissertation
Author: Schaarenburg, R.A. van
Title: The role of C1q in (auto) immunity
Issue Date: 2017-04-12
The role of C1q in (auto) immunity
Rosanne Annelies van Schaarenburg
The role of C1q in (auto) immunity
©Rosanne van Schaarenburg, 2017
All rights are reserved. No part of this thesis may be reproduced, stored, or transmitted in any form or by any means without permission of the copyright owners.
Cover design: Arthur de Haan
ISBN: 978-94-6295-590-5
Printing: ProefschriftMaken Vianen
The research described in this thesis was performed at the department of Rheumatology of the Leiden University Medical Center, Leiden University, Leiden, The Netherlands. The research was supported by the Dutch Organization for Scientific Research (Vidi grant).
Financial support by the NVLE foundation for the publication of this thesis is gratefully acknowledged.
Printing of the thesis was also financially supported by the Leiden University Medical Center, Leiden University and Inova Diagnostics.
The role of C1q in (auto) immunity
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 12 april 2017
Klokke 11:15 uur
door
Rosanne Annelies van Schaarenburg geboren te Zoeterwoude
in 1988
Promotores: Prof. Dr. R.E.M. Toes Prof. Dr. T.W.J. Huizinga
Co-promotor: Dr. L.A. Trouw
Leden promotiecommissie: Prof. Dr. C. Van Kooten, Universiteit Leiden Prof. Dr. A.C. Lankester, Univeristeit Leiden Dr. D. Wouters, Sanquin Amsterdam
Dr. G.M. Steup-Beekman, Universiteit Leiden Dr. S.H.M. Rooijakkers, Universiteit Utrecht Prof. Dr. P.W.H.I. Parren, Univeristeit Leiden
Voor mijn Ouders
Chapter 1 Introduction 9 Part I The clinical association of C1q and anti-C1q 35 Chapter 2 Identification of a novel non-coding mutation in C1qB
in a Dutch child with C1q deficiency with recurrent infections
Immunobiology, van Schaarenburg 2015
37
Chapter 3 Marked variability in clinical presentation and outcome of patients with C1q deficiency
J Autoimmun, van Schaarenburg 2015
53
Chapter 4 C1q deficiency and neuropsychiatric systemic lupus erythematosus
Frontiers Immunol, van Schaarenburg & Magro-Checa 2016
67
Chapter 5 Complement activation and anti-C1q autoantibodies in patients with neuropsychiatric systemic lupus erythematosus
Lupus, van Schaarenburg & Magro-Checa 2016
85
Part II The local production of C1q by immune and non-
immune cells 105
Chapter 6 The production and secretion of complement component C1q by human mast cells
Mol. Immunol. van Schaarenburg 2016
107
Chapter 7 Human chondrocytes produce and secrete C1q
Manuscript in preparation 123
Chapter 8 Summary and discussion 137
Chapter 9 Nederlandse samenvatting Curriculum Vitae
List of publications Acknowledgement
149 154 155 157
