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The handle http://hdl.handle.net/1887/50085 holds various files of this Leiden University dissertation
Author: Kokje, Vivianne
Title: Pharmaceutical stabilization of abdominal aortic aneurysms : changing its natural history
Issue Date: 2017-06-28
PHARMACEUTICAL STABILIZATION OF ABDOMINAL AORTIC ANEURYSMS
Changing its natural history
Vivianne B. C. Kokje
the author.
PHARMACEUTICAL STABILIZATION OF ABDOMINAL AORTIC ANEURYSMS
Changing its natural history
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 28 juni 2017
klokke 15.00 uur
door
Vivianne Beatrix Christina Kokje geboren te Delft
in 1987
PROMOTIECOMMISSIE
Prof. A.J. van Zonneveld Prof. dr. M.J.Th.H. Goumans
Prof. dr. R. Balm (Academisch Medisch Centrum, Amsterdam) dr. P.W.E.H. Vriens (Elizabeth Tweesteden Ziekenhuis, Tilburg)
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
The research described in this thesis was performed at the department of Vascular Surgery of the Leiden University Medical Center, Leiden, The Netherlands and the Stanford University, California, United States of America.
‘Life is not waiting for the storm to pass, it’s about learning how to dance in the rain.’
Anonymous
Voor mijn ouders
TABLE OF CONTENTS
Chapter 1 Introduction 9
Chapter 2 Pharmaceutical management of small Abdominal Aortic
Aneur ysms, a systematic review of the clinical evidence 21 Chapter 3 An association between Chronic Obstructive Pulmonar y Disease
and Abdominal Aortic Aneur ysm beyond smoking
Results from a case- control study 43
Chapter 4 Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in
the Abdominal Aortic Aneur ysm 55
Chapter 5 Inhibition of cysteine protease activity reduces aneur ysm
expansion through decreased matrix degradation 69 Chapter 6 C XCL8 hypersignaling in the Aortic Abdominal Aneur ysm:
the oral C XCR2 antagonist DF2156A fully abrogates
experimental aneur ysm formation 83
Chapter 7 Colchicine inhibits aortic aneur ysm formation in
a rodent model 97
Chapter 8 IL-6: a Janus-like factor in Abdominal Aortic Aneur ysm disease 111 Chapter 9 Adventitial Adipogenic Degeneration is an
Unidentified Contributor to Aortic Wall Weakening in
the Abdominal Aortic Aneur ysm 129
Chapter 10 Summar y and general discussion 147
Chapter 11 Nederlandse Samenvatting 157
Appendix List of publications 169
Dankwoord 170
Curriculum Vitae 17 1
