Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/61631
Author: Kleinovink, E.W.J.
Title: The use of light in cancer immunotherapy
Issue Date: 2018-04-19
The use of light in cancer immunotherapy
Jan Willem Kleinovink
The use of light in cancer immunotherapy
Jan Willem Kleinovink
The research described in this thesis was performed at the department of Immunohematology and Blood Transfusion of the Leiden University Medical Center in the Netherlands, in the context of the Cancer Vaccine Tracking project (#03O-302) of the Center for Translational Molecular Medicine (CTMM).
Layout: Jan Willem Kleinovink Cover design: Jan Willem Kleinovink Thesis printing: Off Page (Amsterdam) ISBN: 978-94-6182-882-8
All rights reserved. Nothing from this thesis may be reproduced in any form without permission from the author.
Copyright © 2018 Jan Willem Kleinovink
The use of light in cancer immunotherapy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op
donderdag 19 april 2018 klokke 15:00 uur
door
Evert Jan Willem Kleinovink geboren te Den Ham in 1986
PROMOTORES
Prof. Dr. F.A. Ossendorp
Prof. Dr. C.W.G.M. Löwik (Erasmus MC Rotterdam)
CO-PROMOTOR
Dr. M.F. Herbert-Fransen
LEDEN PROMOTIECOMMISSIE Prof. Dr. M. Jager
Prof. Dr. W. Jiskoot
Dr. S. Oliveira (Universiteit Utrecht)
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Table of Contents
Chapter 1 7
General Introduction
Chapter 2 21
Combination of Photodynamic Therapy and specific immunotherapy efficiently eradicates established tumors
Chapter 3 43
Photodynamic-immune checkpoint therapy eradicates local and distant tumors by CD8+ T cells
Chapter 4 57
Vaccine tracking by in vivo near-infrared fluorescence imaging of emulsified peptide antigen
Chapter 5 71
Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8+ T cell immune response
Chapter 6 93
A dual-color bioluminescence reporter mouse for simultaneous in vivo imaging of T cell localization and activation
Chapter 7 111
Summary and General Discussion
Appendices Nederlandse samenvatting 123
Dankwoord 131
Curriculum Vitae 133
List of Publications 135
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