Citation
Heidt, S. (2010, March 3). Characterization of B cell responses in relation to organ transplantation. Retrieved from https://hdl.handle.net/1887/15051
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/15051
Note: To cite this publication please use the final published version (if applicable).
CHARACTERIZATION OF B CELL RESPONSES IN RELATION TO
ORGAN TRANSPLANTATION
CHARACTERIZATION OF B CELL RESPONSES IN RELATION TO ORGAN TRANSPLANTATION
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 3 maart 2010 klokke 15:00 uur
door
SEBASTIAAN HEIDT geboren te Zoeterwoude
in 1979
© 2010 Sebastiaan Heidt, Leiden, the Netherlands
Characterization of B cell responses in relation to organ transplantation
The research described in this thesis was performed at the Department of Immunohaematology and Blood Transfusion of the Leiden University Medical Center and was financially supported by the Landsteiner Stichting voor Bloedtransfusie Research, the National Reference Center for Histocompatibility Testing and RISET FP6.
ISBN 978-94-61080-13-4
Cover design and layout: Sebastiaan Heidt
Printed by: Gildeprint Drukkerijen - Enschede, the Netherlands
Financial support for the publication of this thesis was kindly provided by: Symbio Herborn Group, Stichting NRC, Astellas Pharma B.V., Novartis Pharma B.V., Baxter B.V., BD Biosciences, Greiner Bio-One, VPS Diagnostics, Clean Air Techniek B.V., Genome Diagnostics, Millipore B.V. and Corning B.V.
aan mijn ouders Every little piece of your life will mean something to someone Editors – The Weight of the World
TABLE OF CONTENTS
1. General introduction
2. Effects of immunosuppressive drugs on purified human B cells;
evidence supporting the use of MMF and rapamycin (Transplantation 2009; 86(9): 1292-1300)
3. Calcineurin inhibitors affect B cell antibody responses by interfering with T cell help
(Clinical and Experimental Immunology 2010; 159 (2): 199-207)
4. Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production
(Clinical and Experimental Immunology 2009; 158 (I): 99-105)
5. Bortezomib affects the function of human B cells: possible implications for humoral rejection therapy
6. A novel ELISPOT assay to quantify HLA-specific B cells in HLA- immunized individuals
(Manuscript in preparation)
7. Monitoring of indirect allorecognition: wishful thinking or solid data?
(Tissue Antigens 2008; 71(1): 1-15)
8. General discussion and conclusions
9. Nederlandse samenvatting
Abbreviations Publications Curriculum Vitae
9
33
53
71
85
91
107
137
149
157 163 167
