Endocrine and metabolic effects of antipsychotic drugs
Vidarsdóttir, S.
Citation
Vidarsdóttir, S. (2010, January 14). Endocrine and metabolic effects of antipsychotic drugs. Retrieved from https://hdl.handle.net/1887/15200
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/15200
Note: To cite this publication please use the final published version (if
applicable).
Endocrine and metabolic effects of antipsychotic drugs
Cover photo: Guilherme Marconi, from the series ‘My schizophrenic brain’
Printed by: Optima Grafische Communicatie, Rotterdam.
ISBN: 978-90-8859-611-0
© 2010, Sólrún Vidarsdóttir, The Hague, The Netherlands. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without written permis- sion of the author, or where appropriate, of the publisher of the articles.
Endocrine and metabolic effects of antipsychotic drugs
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 14 januari 2010
klokke 16.15 uur
door
Sólrún Vidarsdóttir
geboren te Reykjavík, IJsland in 1966
PROMOTIECOMMISSIE:
Promotores Prof. dr. H. Pijl Prof. dr. J.A. Romijn
Co-promotor Dr. F. Roelfsema
Overige commissieleden Prof. dr. E. Fliers
Mw. Dr. M. Frölich Dr. E.J.P. de Koning Prof. dr. J.W.A. Smit Prof. dr. C.J.J. Tack
The study described in this thesis was performed at the Leiden University Medical Center, Leiden, The Netherlands. The research was financially supported by the Diabetes Dutch Foun- dation (Project 2002.01.005) and Eli Lilly.
Contents
Chapter 1
General Introduction 7
Chapter 2
Effects of olanzapine and haloperidol on the metabolic status of healthy men 23
Chapter 3
Orally disintegrating and standard olanzapine tablets similarly elevate the HOMA insulin resistance index and plasma triglyceride levels in healthy men
39
Chapter 4
Olanzapine shifts the temporal relationship between the daily acrophase of serum prolactin and cortisol concentration rhythm in healthy men
55
Chapter 5
Short-term treatment with olanzapine does not modulate gut hormone secretion;
Olanzapine disintegrating versus standard tablets
71
Chapter 6
Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes mellitus
87
Chapter 7
General discussion 97
Chapter 8
Summary and conclusions 109
Samenvatting en conclusies 115
List of publications 119
Nawoord 121
Curriculum Vitae 123
