• No results found

Spatial and dynamic organization of molecular structures in the cell nucleus

N/A
N/A
Info
Downloaden
Protected

Academic year: 2021

Share "Spatial and dynamic organization of molecular structures in the cell nucleus"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Download het nu ( 7 pagina )

Hele tekst

(1)

Spatial and dynamic organization of molecular structures in the cell nucleus

Brouwer, A.K.

Citation

Brouwer, A. K. (2010, September 8). Spatial and dynamic organization of molecular structures in the cell nucleus. Retrieved from https://hdl.handle.net/1887/15930

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15930

Note: To cite this publication please use the final published version (if applicable).

(2)

Spatial and Dynamic Organization of Molecular Structures in the Cell

Nucleus

Anne – Kee Brouwer

(3)
(4)

Spatial and Dynamic Organization of Molecular Structures in the Cell Nucleus

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op woensdag 8 september 2010 klokke 13.45 uur

door

Anne - Kee Brouwer

geboren te Amsterdam

in 1976

(5)

Promotiecommissie

Promotor: Prof. dr. H.J. Tanke

Co-promotor: Dr. R.W. Dirks

Commissieleden: Prof. dr. L.H.F. Mullenders

Dr. J.M.J.M. Zijlmans Erasmus Universiteit Rotterdam Prof. dr. F.C.S. Ramaekers Universiteit Maastricht

The studies described in this thesis were performed at the department of Molecular Cell Biology, Leiden University Medical Center.

Printing of this thesis was financially supported by the J.E. Jurriaanse Stichting.

This thesis was printed by F&N Boekservice, Amsterdam.

(6)

Table of contents

Chapter 1 Introduction and outline of the thesis 9 Chapter 2 STACKS: A software program for particle tracking in

living cells 61 59

Chapter 3 Telomere movement is constrained by interactions with an

inner

inner nuclear lamin structure 85 Chapter 4 Telomeric DNA mediates de novo PML body formation 105

Chapter 5 Nuclear body movement is constrained by associations

with chromatin 143 Chapter 6 Summary and discussion 165

Nederlandse samenvatting 175

Curriculum vitae 179

(7)

Referenties

Download het nu ( PDF - 7 pagina - 108.81 KB )

GERELATEERDE DOCUMENTEN

Spatial and dynamic organization of molecular structures in the cell nucleus

Be- cause of their association to a nuclear matrix structure, telomeres are thought to play an important role in nuclear organization (de Lange, 2002). In situ hybridization

Spatial and dynamic organization of molecular structures in the cell nucleus

of the IEEE International Conference on Multime- dia & Expo (ICME 2006), July 9-12, Toronto, Ontario, Canada. Francastel C., Schubeler D., Martin D.I. Nuclear

Spatial and dynamic organization of molecular structures in the cell nucleus

Recently, we showed that lamin redistribution in the cell nucleus is one of the first hallmarks of a senescent state of mesenchymal stem cells and that this redis- tribution

Spatial and dynamic organization of molecular structures in the cell nucleus

To confirm our findings using nontransfected U2OS cells, we analyzed the formation of PML bodies in 10 U2OS cells that were allowed to recover from MMS treatment and were fixed

Spatial and dynamic organization of molecular structures in the cell nucleus

Consistent with data showing that PML bodies, Cajal bodies and speckles associate with specific chromatin loci, our results suggest that nuclear bodies are relatively immobile in

Spatial and dynamic organization of molecular structures in the cell nucleus

By com- bining tools in live cell imaging, immunocytochemistry and molecular cell biology, this Thesis offers new insights in the structural organization of the cell nucleus and in

Spatial and dynamic organization of molecular structures in the cell nucleus

Om te onderzoeken of deze lamine-eiwitten mogelijk betrokken zijn bij de positionering van telomeren is RNA interferentie toegepast om de expressie van de lamine-eiwitten lamine

Spatial and dynamic organization of molecular structures in the cell nucleus

From Januari 2004 until Februari 2009 Anneke Brouwer was employed by the Leiden University as a PhD student at the Nuclear Organi- zation and Gene Function group, Department