Funtional and applied studies on the
adenovirus minor capsid protein IX
Vellinga, J.
Citation
Vellinga, J. (2006, June 29). Funtional and applied
studies on the adenovirus minor capsid protein IX.
Retrieved from https://hdl.handle.net/1887/4461
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Corrected Publisher’s Version
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Functional and applied studies on the adenovirus minor capsid protein IX
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties te verdedigen op donderdag 29 juni 2006
klokke 14.15 uur door
Jort Vellinga geboren te Capelle aan den IJssel
Promotiecommissie
Promotor: Prof. Dr. R.C. Hoeben Referent: Prof. Dr. P.C. van der Vliet (UMCU) Overige Leden: Prof. Dr. E.J.H.J. Wiertz
Prof. Dr. T. Vandendriessche (KULeuven) Dr. V.W. van Beusechem (VUMC) Dr. E.J. Snijder
Contents
Chapter 1 Introduction 5
Chapter 2 The adenovirus capsid: major progress in minor proteins 15
Chapter 3 Spacers increase the accessibility of peptide ligands linked to the 29 carboxyl terminus of adenovirus minor capsid protein IX
Chapter 4 A system for efficient generation of adenovirus protein IX-producing 47 helper cell lines
Chapter 5 Efficient incorporation of a functional hyper stable single-chain antibody 63 fragment protein-IX fusion in the adenovirus capsid
Chapter 6 The coiled-coil domain of the adenovirus type 5 protein IX is dispensable 75 for capsid incorporation and thermostability
Chapter 7 Conclusive remarks (summary) 87
Samenvatting 91
List of publications 93
