Cover Page
The handle http://hdl.handle.net/1887/123057 holds various files of this Leiden University dissertation.
Author: Ren, J.
Regulation of BMP and TGFβ
Signaling Pathway in
Cancer Progression
ISBN: 978-94-028-2085-0
Cover: GREM1 RNA staining by using in situ hybridization in a breast cancer tissue.
© 2020, Jiang Ren, Leiden, the Netherlands. All rights reserved. No part of this thesis may be reproduced, stored, translated or transmitted in any form or by any means now or hereafter, electronic or mechanical without prior written permission from the author.
Cover design & layout by Jiang Ren. Printed by Ipskamp Printing
Regulation of BMP and TGFβ
Signaling Pathway in
Cancer Progression
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag, 24 juni, 2020
klokke 10:00 uur
door
Jiang Ren
Promotor:
Prof. Dr. P. ten Dijke
Leden promotiecommissie:
Prof. Dr. M. J. Goumans
Prof. Dr. A. Moustakas (Uppsala University)
CONTENTS
Introduction and Outline of the Thesis 7
Chapter 1 Bone Morphogenetic Proteins in the Initiation and Progression of
Breast Cancer 15
Chapter 2 Invasive Behavior of Human Breast Cancer Cells in Embryonic
Zebrafish 47
Chapter 3 Cancer-associated Fibroblast-derived Gremlin 1 Promotes Breast
Cancer Progression 67
Chapter 4 Synergistic Reactivation of BMP Signaling by MEK Inhibitor and
FK506 Reduces Breast Cancer Metastasis 109
Chapter 5 JUNB Governs a Feed-forward Network of TGFβ Signaling that
Aggravates Breast Cancer Invasion 141
Chapter 6 Combined Inhibition of TGFβ Signaling and the PD-L1 Immune
Checkpoint Is Differentially Effective in Tumor Models 181
Summary and Perspectives 203
Addendum Nederlandse Samenvatting 210
List of Abbreviations 213
List of Publications 216
Curriculum Vitae 217
