University of Groningen
The identification of cell non-autonomous roles of astrocytes in neurodegeneration
Li, Yixian
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Publication date: 2018
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Li, Y. (2018). The identification of cell non-autonomous roles of astrocytes in neurodegeneration. University of Groningen.
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The identification of
cell non-autonomous roles of
astrocytes in neurodegeneration
ISBN: 978-94-034-0765-4
The research described in this thesis was performed at the Department of Cell Biology, University Medical Center Groningen, University of Groningen, the Netherlands.
Cover and layout design: ThesisExpert.nl Printed by Gildeprint, Enschede, the Netherlands
The printing of this thesis was financially supported by the University of Groningen and University Medical Center Groningen.
Copyright © 2018 by Yixian Li. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.
The identification of
cell non-autonomous roles of
astrocytes in neurodegeneration
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Monday 11 June 2018 at 16.15 hours
by
Yixian Li
born on 1 June 1986 in Beijing, China
Supervisor Prof. O.C.M. Sibon Co-supervisor Dr. P.F. Dijkers
Assessment Committee Prof. B.J.L. Eggen Prof. E.M. Hol Prof. D.S. Verbeek
TABLE OF CONTENTS
Chapter 1 General Introduction
Chapter 2 A Drosophila screen elucidates roles for signaling
molecules in cell non-autonomous effects of astrocytes on neurodegenerative disease
Chapter 3 Inhibition of NF-κB in astrocytes delays neurodegeneration in a cell non-autonomous manner
Chapter 4 Specific calcineurin isoforms are involved in Drosophila Toll immune signaling
Chapter 5 General discussion Summary Samenvatting Acknowledgemetns 8 26 54 84 108 116 120 124 128
