University of Groningen
Unraveling clonal heterogeneity in acute myeloid leukemia de Boer, Bauke
DOI:
10.33612/diss.113125010
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
de Boer, B. (2020). Unraveling clonal heterogeneity in acute myeloid leukemia. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.113125010
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Unraveling clonal heterogeneity in
Unraveling clonal heterogeneity in
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Bauke de Boer
Bauke de Boer
The research described in this thesis was performed at the Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
This research has been funded by the European Research Council (ERC-2011-StG 281474-huLSCtargeting).
Printing of this thesis was financially supported by University of Groningen, UMCG Graduate School of Medical Sciences and the Department of Hematology
ISBN print: 978-94-6375-763-8 ISBN e-book: 978-94-6375-788-1 Cover and lay-out: Bauke de Boer
Print: Ridderprint | www.ridderprint.nl Copyright © 2020 by Bauke de Boer.
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without written permission of the author.
Unraveling clonal heterogeneity in
Acute Myeloid Leukemia
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 9 september 2020 om 11.00 uur
door
Bauke de Boer
geboren op 27 oktober 1989 te Wûnseradiel
Promotores Promotores Prof. dr. J.J. Schuringa Prof. dr. E. Vellenga Beoordelingscommissie Beoordelingscommissie Prof. dr. C. Bonifer Prof. dr. R. Delwel Prof. dr. G. de Haan
Paranimfen
Paranimfen
Alan Cunningham Sybold Bas de Boer
Table of contents
Table of contents
Chapter 1Chapter 1 General introductionGeneral introduction Scope of this thesis Scope of this thesis Chapter 2
Chapter 2 Genetically engineered mesenchymal stromal cells Genetically engineered mesenchymal stromal cells produce IL3 and TPO to further improve human produce IL3 and TPO to further improve human scaffold-based xenograft models
scaffold-based xenograft models
Experimental Hematology 2017 July; 51:36-46Experimental Hematology 2017 July; 51:36-46
Chapter 3
Chapter 3 Prospective isolation and characterization of genetically Prospective isolation and characterization of genetically and functionally distinct AML subclones
and functionally distinct AML subclones
Cancer Cell 2018 October 8;34(4):674-689Cancer Cell 2018 October 8;34(4):674-689 Chapter 4
Chapter 4 The IL1-IL1RAP axis plays an important role in the The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors AML survival inflammatory leukemic niche that favors AML survival over normal hematopoiesis
over normal hematopoiesis
SubmittedSubmitted
Chapter 5
Chapter 5 Summary, discussion, future perspectives, and Summary, discussion, future perspectives, and concluding remarks
concluding remarks Appendices
Appendices Nederlandse SamenvattingNederlandse Samenvatting Acknowledgements Acknowledgements Biography Biography List of publications List of publications 99 29 29 55 55 109 109 137 137 161 161
