University of Groningen
Molecular insights into viral respiratory infections Cong, Ying-Ying
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Publication date: 2019
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Cong, Y-Y. (2019). Molecular insights into viral respiratory infections. University of Groningen.
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Molecular insights into
viral respiratory infections
The research presented in this thesis was performed at the Department of Biomedical Sciences of Cell & Systems, Medical Center Groningen, University of Groningen, University Groningen, The Netherlands
The research conducted in this thesis was financially supported by
China Scholarship Council (CSC) University Medical Center Groningen Microbes Health and Disease
Paranymphs
Verlhac Pauline Xingdong Zhou
The printing of this thesis was financially supported by
University of Groningen
University Medical Center Groningen Microbes Health and Disease
Cover designed by Y. Cong, X. Zhou and TM DESIGN Printed by Proefschrift Maken, Utrecht
ISBN: 978-94-034-1361-7 ISBN: 978-94-034-1360-0 (Ebook)
Copyright © 2019 Y. Cong. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without prior written permission of the author and the publishers holding the copyrights of the published articles.
Molecular insights into
viral respiratory infections
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Wednesday 6 February 2019 at 14.30 hours
by
Yingying Cong
born on 6 October 1988Supervisors
Prof. F.M. Reggiori Prof. A.L.W. Huckriede
Assessment Committee
Prof. S.C.D. van IJzendoorn Prof. J.M. Smit
TABLE OF CONTENTS
Chapter I General Introduction 8
Chapter II The Interaction between Nidovirales and Autophagy 37
Components Chapter III Ultrastructural characterization of membrane 59
rearrangements induced by porcine epidemic diarrhea virus infection Chapter IV Coronavirus nucleocapsid proteins assemble 93
constitutively in high molecular oligomers Chapter V The recruitment of mouse hepatitis virus (MHV) 121
nucleocapsid protein to replication-transcription complexes plays a key role in infection Chapter VI LC3 proteins play a crucial role in influenza virus 159
infection Summary and Pespective 190
Nederlandse Samenvatting 202
Acknowledgements 206
