University of Groningen
Cell-autonomous and non-cell autonomous protection of DNAJB6 in Huntington’s disease Bason, Matteo
DOI:
10.33612/diss.101925993
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Bason, M. (2019). Cell-autonomous and non-cell autonomous protection of DNAJB6 in Huntington’s disease. University of Groningen. https://doi.org/10.33612/diss.101925993
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Cell-autonomous
and non-cell autonomous protection
of DNAJB6
in Huntington’s disease
Matteo Bason
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The research described in this thesis was conducted at the Department of Cell Biology, University Medical Center Groningen, University of Groningen, The Netherlands.
This research was supported by the Prinses Beatrix Foundation / de Nederlandse Hersenstichting (grant # F2012(1)-104).
Cover designed by Matteo Bason and Ilse Modder (artwork: ‘Study of Hands’, Albrecht Dürer, 1506)
Thesis printed by Gilderprint ISBN (print): 9789463238885 ISBN (electronic): 9789463238885
Copyright©2019 by Matteo Bason. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without permission of the author.
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Cell-autonomous and non-cell
autonomous protection of DNAJB6
in Huntington’s disease
PhD Thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on 2 December 2019 at 9:00 hours
by
Matteo Bason
born on 04 August 1983 in Brescia, Italy
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Supervisors:
Prof. H.H. Kampinga
Prof. H.W.G.M. Boddeke
Assessment Committee:
Prof. E.A.J. Reits
Prof. Y. Nagai
Prof. U.L.M. Eisel
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Paranymphs
Despina Serlidaki
Marco dal Lago
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Table of contents
Chapter 1: Outline of the Thesis
Page 9Chapter 2: Introduction
Page 13Chapter 3: A D.melanogaster model for the expression of
transgenes in neurons and astrocytes
Page 89
Chapter 4: Neuronal expression of the chaperone DNAJB6 results
in cell autonomous protection in Huntington’s disease
Page 105
Chapter 5: Astrocytic expression of the chaperone DNAJB6 results
in non-cell autonomous protection in Huntington’s disease
Page 125
