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University of Groningen Cross-protection induced by influenza: from infection to vaccines Dong, Wei

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University of Groningen

Cross-protection induced by influenza: from infection to vaccines

Dong, Wei

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Dong, W. (2018). Cross-protection induced by influenza: from infection to vaccines. University of Groningen.

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Cross-protection induced by influenza: from

infection to vaccines

Wei Dong

董伟

(3)

The research described in my thesis was performed at the Department of Medical Microbiology of the University Medical Center Groningen (UMCG), University of Groningen, the Netherlands, and partly in Shantou University Medical college, Shantou, China.

The printing of this thesis was financially supported by the University of Groningen, the Groningen University Institute for Drug Exploration (GUIDE).

Cover design: Remco Wetzels Layout: Wei Dong

Printing: Ridderprint BV – www.ridderprint.nl

ISBN: 978-94-6375-182-7 (digital verstion)

ISBN:978-94-6375-143-8 (hardcopy)

© Copyright 2018 Wei Dong. All rights reserved. No part of this publication may be reproduced in any form or by any means, without permission of the author.

Cross-protection induced by influenza:

from infection to vaccines

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans.

This thesis will be defended in public on

Monday 12 November 2018 at 4.15 hours

by

Wei Dong

born on 21 October 1986 in Hubei, China

(4)

The research described in my thesis was performed at the Department of Medical Microbiology of the University Medical Center Groningen (UMCG), University of Groningen, the Netherlands, and partly in Shantou University Medical college, Shantou, China.

The printing of this thesis was financially supported by the University of Groningen, the Groningen University Institute for Drug Exploration (GUIDE).

Cover design: Remco Wetzels Layout: Wei Dong

Printing: Ridderprint BV – www.ridderprint.nl

ISBN: 978-94-6375-182-7 (digital verstion)

ISBN:978-94-6375-143-8 (hardcopy)

© Copyright 2018 Wei Dong. All rights reserved. No part of this publication may be reproduced in any form or by any means, without permission of the author.

Cross-protection induced by influenza:

from infection to vaccines

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans.

This thesis will be defended in public on

Monday 12 November 2018 at 4.15 hours

by

Wei Dong

born on 21 October 1986 in Hubei, China

(5)

Supervisors

Prof. A.L.W. Huckriede Prof. dr. D. Kelvin Assessment Committee Prof. dr. C. McCormick Prof. P. Heeringa Prof. dr. E. Hak Paranymphs

Jacqueline de Vries Idema Qiong Jiang

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Supervisors

Prof. A.L.W. Huckriede Prof. dr. D. Kelvin Assessment Committee Prof. dr. C. McCormick Prof. P. Heeringa Prof. dr. E. Hak Paranymphs

Jacqueline de Vries Idema Qiong Jiang

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CONTENTS

Chapter 1

Introduction and scope of the thesis 9

Chapter 2 Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines 37

Chapter 3 Cross-protective potential and protection-relevant immune mechanisms of whole inactivated influenza virus vaccines are determined by adjuvants and route of immunization 63

Chapter 4 Monophosphoryl lipid A-adjuvanted virosomes with Ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine 91

Chapter 5 Streptococcus pneumoniae infection affects immune responses to influenza vaccination 115 Chapter 6 Experiences of using the cotton rat model for influenza vaccine evaluation 127

Chapter 7 Summarizing discussion 151 Appendices 169 Nederlandse samenvatting 170 Acknowledgements 175 Curriculum Vitae 178 List of publications 179

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CONTENTS

Chapter 1

Introduction and scope of the thesis 9

Chapter 2 Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines 37

Chapter 3 Cross-protective potential and protection-relevant immune mechanisms of whole inactivated influenza virus vaccines are determined by adjuvants and route of immunization 63

Chapter 4 Monophosphoryl lipid A-adjuvanted virosomes with Ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine 91

Chapter 5 Streptococcus pneumoniae infection affects immune responses to influenza vaccination 115 Chapter 6 Experiences of using the cotton rat model for influenza vaccine evaluation 127

Chapter 7 Summarizing discussion 151 Appendices 169 Nederlandse samenvatting 170 Acknowledgements 175 Curriculum Vitae 178 List of publications 179

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