University of Groningen
Cross-protection induced by influenza: from infection to vaccines
Dong, Wei
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Publication date: 2018
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Dong, W. (2018). Cross-protection induced by influenza: from infection to vaccines. University of Groningen.
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Cross-protection induced by influenza: from
infection to vaccines
Wei Dong
董伟
The research described in my thesis was performed at the Department of Medical Microbiology of the University Medical Center Groningen (UMCG), University of Groningen, the Netherlands, and partly in Shantou University Medical college, Shantou, China.
The printing of this thesis was financially supported by the University of Groningen, the Groningen University Institute for Drug Exploration (GUIDE).
Cover design: Remco Wetzels Layout: Wei Dong
Printing: Ridderprint BV – www.ridderprint.nl
ISBN: 978-94-6375-182-7 (digital verstion)
ISBN:978-94-6375-143-8 (hardcopy)
© Copyright 2018 Wei Dong. All rights reserved. No part of this publication may be reproduced in any form or by any means, without permission of the author.
Cross-protection induced by influenza:
from infection to vaccines
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans.
This thesis will be defended in public on
Monday 12 November 2018 at 4.15 hours
by
Wei Dong
born on 21 October 1986 in Hubei, ChinaThe research described in my thesis was performed at the Department of Medical Microbiology of the University Medical Center Groningen (UMCG), University of Groningen, the Netherlands, and partly in Shantou University Medical college, Shantou, China.
The printing of this thesis was financially supported by the University of Groningen, the Groningen University Institute for Drug Exploration (GUIDE).
Cover design: Remco Wetzels Layout: Wei Dong
Printing: Ridderprint BV – www.ridderprint.nl
ISBN: 978-94-6375-182-7 (digital verstion)
ISBN:978-94-6375-143-8 (hardcopy)
© Copyright 2018 Wei Dong. All rights reserved. No part of this publication may be reproduced in any form or by any means, without permission of the author.
Cross-protection induced by influenza:
from infection to vaccines
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans.
This thesis will be defended in public on
Monday 12 November 2018 at 4.15 hours
by
Wei Dong
born on 21 October 1986 in Hubei, China
Supervisors
Prof. A.L.W. Huckriede Prof. dr. D. Kelvin Assessment Committee Prof. dr. C. McCormick Prof. P. Heeringa Prof. dr. E. Hak Paranymphs
Jacqueline de Vries Idema Qiong Jiang
Supervisors
Prof. A.L.W. Huckriede Prof. dr. D. Kelvin Assessment Committee Prof. dr. C. McCormick Prof. P. Heeringa Prof. dr. E. Hak Paranymphs
Jacqueline de Vries Idema Qiong Jiang
CONTENTS
Chapter 1
Introduction and scope of the thesis 9
Chapter 2 Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines 37
Chapter 3 Cross-protective potential and protection-relevant immune mechanisms of whole inactivated influenza virus vaccines are determined by adjuvants and route of immunization 63
Chapter 4 Monophosphoryl lipid A-adjuvanted virosomes with Ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine 91
Chapter 5 Streptococcus pneumoniae infection affects immune responses to influenza vaccination 115 Chapter 6 Experiences of using the cotton rat model for influenza vaccine evaluation 127
Chapter 7 Summarizing discussion 151 Appendices 169 Nederlandse samenvatting 170 Acknowledgements 175 Curriculum Vitae 178 List of publications 179
CONTENTS
Chapter 1
Introduction and scope of the thesis 9
Chapter 2 Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines 37
Chapter 3 Cross-protective potential and protection-relevant immune mechanisms of whole inactivated influenza virus vaccines are determined by adjuvants and route of immunization 63
Chapter 4 Monophosphoryl lipid A-adjuvanted virosomes with Ni-chelating lipids for attachment of conserved viral proteins as cross-protective influenza vaccine 91
Chapter 5 Streptococcus pneumoniae infection affects immune responses to influenza vaccination 115 Chapter 6 Experiences of using the cotton rat model for influenza vaccine evaluation 127
Chapter 7 Summarizing discussion 151 Appendices 169 Nederlandse samenvatting 170 Acknowledgements 175 Curriculum Vitae 178 List of publications 179
