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University of Groningen

Modulating the immune system and intestinal barrier integrity with functional oligosaccharides

Figueroa Lozano, Susana

DOI:

10.33612/diss.151659844

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

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Publication date:

2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Figueroa Lozano, S. (2021). Modulating the immune system and intestinal barrier integrity with functional

oligosaccharides. University of Groningen. https://doi.org/10.33612/diss.151659844

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Modulating the immune system

and intestinal barrier integrity

with functional oligosaccharides

Susana Figueroa Lozano-de Vrij

2021

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The work described in this thesis was carried out at the Department of Pathology and Medical Biology at the University Medical Center Groningen (UMCG), University of Groningen, and was financially supported by the University of Groningen/Campus Fryslân, the University of Groningen.

Printing of this thesis was financially supported by the University Library of the University of Groningen.

Modulating the immune system and intestinal barrier integrity with functional oligosaccharides

Layout & cover design: Emilia Bigaeva

Printing: Ipskamp Printing, Enschede

© Copyright 2020-2021, Susana Figueroa Lozano

All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic or mechanical, without permission of the author.

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Modulating the immune system

and intestinal barrier integrity with

functional oligosaccharides

PhD Thesis

to obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus prof. Cisca Wijmenga

and in accordance with

the decision by the College of Deans

This thesis will be defended in public on

Tuesday 2 February 2021 at 11.00 hours

by

Fanny Susana Figueroa Lozano

Born on 26 October 1978

Santafé de Bogotá, Colombia

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Supervisor Prof. P. de Vos Co-supervisor Dr. M.M. Faas Assessment Committee Prof. H. Schols Prof. L. Dijkhuizen Prof. T. Plosch Paranymphs Emilia Bigaeva Emilia Gore

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To my dear parents

Pedro Figueroa

and

Blanca Lozano

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1

2

4

3

5

6

7

8

Relationship Between Oligosaccharides and

Glycoconjugates Content in Human Milk and

the Development of the Gut Barrier

9

Dietary N-glycans from Bovine Lactoferrin

and TLR Modulation

49

Inhibitory Effects of Dietary N-Glycans from

Bovine Lactoferrin on Toll-Like Receptor 8

77

The Impact of Oligosaccharide Content,

Glycosidic Linkages and Lactose Content of

Galacto-Oligosaccharides (GOS) on the

Expression of Mucus-Related Genes in Goblet Cells

101

2’-Fucosyllactose Impacts the Expression

of Mucus-Related Genes in Goblet Cells and

Maintains Barrier Function of Gut Epithelial Cells

125

General Discussion

145

Summary

English

Nederlands

Español

160

164

168

Abbreviations

Author affiliations

List of publications

About the author

Acknowledgements

174

176

178

179

180

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