University of Groningen
Role of hepatic glucose signaling in the development of liver disease
Lei, Yu
DOI:
10.33612/diss.126530476
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Lei, Y. (2020). Role of hepatic glucose signaling in the development of liver disease. University of Groningen. https://doi.org/10.33612/diss.126530476
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Role of Hepatic Glucose Signaling in the
Development of Liver Disease
The work in this thesis was carried out at the Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands and the Department of Pathology, Provincial Key Laboratory of Infectious Diseases and Immunopathology, Collaborative and Creative Center, Shantou University Medical College, Shantou, China.
Printing of this thesis was financially supported by: University of Gronigen
University Medical Center Groningen (UMCG)
Groningen University Institute for Drug Exploration (GUIDE)
Cover design: Yu Lei Layout: Yu Lei
Printed by: Ridderprint | www.ridderprint.nl ISBN: 978-94-6375-923-6
© Yu Lei, 2020.
All rights reserved. No part of this thesis may be reproduced, distributed, stored in a retrieval system, of transmitted in any form or by any means without prior permission of the author.
Role of hepatic glucose signaling in
the development of liver disease
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 10 June 2020 at 9.00 hours
by
Yu Lei
born on 24 February 1989 in Chongqing, China
The work in this thesis was carried out at the Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands and the Department of Pathology, Provincial Key Laboratory of Infectious Diseases and Immunopathology, Collaborative and Creative Center, Shantou University Medical College, Shantou, China.
Printing of this thesis was financially supported by: University of Gronigen
University Medical Center Groningen (UMCG)
Groningen University Institute for Drug Exploration (GUIDE)
Cover design: Yu Lei Layout: Yu Lei
Printed by: Ridderprint | www.ridderprint.nl ISBN: 978-94-6375-923-6
© Yu Lei, 2020.
All rights reserved. No part of this thesis may be reproduced, distributed, stored in a retrieval system, of transmitted in any form or by any means without prior permission of the author.
Role of hepatic glucose signaling in
the development of liver disease
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 10 June 2020 at 9.00 hours
by
Yu Lei
born on 24 February 1989 in Chongqing, China
Promotores
Prof. dr. F. Kuipers Prof. dr. J. GuCo-Promotor
Dr. M.H. OosterveerAssessment Committee
Prof. dr. C.J. de Vries Prof. dr. P. Olinga Prof. dr. A.J. MoshageContent
Chapter 1 General Introduction 7
Chapter 2 Hepatic ChREBP activation limits NAFLD development in a
mouse model for Glycogen Storage Disease type Ia 29
Chapter 3 Glucose-6-phosphate regulates hepatic bile acid synthesis
in mice 61
Chapter 4 ChREBP promotes hepatocyte proliferation in vitro but protects against oncogenic hepatocyte transformation in a mouse model for Glycogen Storage Disease type 1a
93
Chapter 5 Glucose-6-phosphatase deficiency shifts the balance between hepatocyte hyperplasia and hypertrophy during liver regeneration
125
Chapter 6 Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance
143
Chapter 7 General Discussion 161
Appendices English summary
Nederlandse samenvatting Acknowledgements Biography List of publications 181 185 189 193 195
Promotores
Prof. dr. F. Kuipers Prof. dr. J. GuCo-Promotor
Dr. M.H. OosterveerAssessment Committee
Prof. dr. C.J. de Vries Prof. dr. P. Olinga Prof. dr. A.J. MoshageContent
Chapter 1 General Introduction 7
Chapter 2 Hepatic ChREBP activation limits NAFLD development in a
mouse model for Glycogen Storage Disease type Ia 29
Chapter 3 Glucose-6-phosphate regulates hepatic bile acid synthesis
in mice 61
Chapter 4 ChREBP promotes hepatocyte proliferation in vitro but protects against oncogenic hepatocyte transformation in a mouse model for Glycogen Storage Disease type 1a
93
Chapter 5 Glucose-6-phosphatase deficiency shifts the balance between hepatocyte hyperplasia and hypertrophy during liver regeneration
125
Chapter 6 Expressions of Carbohydrate Response Element Binding Protein and Glucose Transporters in Liver Cancer and Clinical Significance
143
Chapter 7 General Discussion 161
Appendices English summary
Nederlandse samenvatting Acknowledgements Biography List of publications 181 185 189 193 195
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