University of Groningen
Role of hepatic glucose signaling in the development of liver disease
Lei, Yu
DOI:
10.33612/diss.126530476
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Document Version
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Lei, Y. (2020). Role of hepatic glucose signaling in the development of liver disease. University of Groningen. https://doi.org/10.33612/diss.126530476
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Propositions
1. Hepatic ChREBP activation limits Non-Alcoholic Fatty Liver Disease development in murine Glycogen Storage Disease type Ia (GSD Ia). – This thesis
2. ChREBP promotes hepatic VLDL-triglyceride secretion in parallel to an induction of the expression of VLDL lipidation proteins MTTP and TM6SF2. – This thesis 3. Hepatic glucose-6-phosphate-ChREBP signaling regulates bile acid and
cholesterol metabolism via up-regulation of sterol 12 α-hydroylase (CYP8B1) activity in mice. – This thesis
4. ChREBP promotes hepatocyte proliferation in vitro but delays in vivo liver tumor development in GSD Ia mice. – This thesis
5. Attenuation of hepatic ChREBP induction in GSD Ia mice promotes DNA damage, chromosomal instability and hepatocyte death – This thesis
6. Hepatocyte G6pc deficiency in mice induces genomic instability and shifts the balance between hepatocyte hyperplasia and hypertrophy during liver regeneration. – This thesis
7. GLUT1 and GLUT2 show opposite expression patterns during human hepatocellular carcinoma (HCC) progression. – This thesis
8. Learning without thought is labor lost, thought without learning is perilous. – Confucius
