University of Groningen
Modulating the immune system and intestinal barrier integrity with functional oligosaccharides
Figueroa Lozano, Susana
DOI:
10.33612/diss.151659844
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Figueroa Lozano, S. (2021). Modulating the immune system and intestinal barrier integrity with functional oligosaccharides. University of Groningen. https://doi.org/10.33612/diss.151659844
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Propositions
Belonging to the dissertation
Modulating the immune system and intestinal barrier integrity with functional oligosaccharides
1. The content of mannose and sialic acid on the glycan portion of bovine lactoferrin has a direct effect on the immunomodulatory capacity of the glycoprotein (this thesis).
2. N-glycans isolated from bovine lactoferrin can inhibit the activation of TLR-8 by preventing conformational changes required for the activation of this receptor (this thesis).
3. N-glycans isolated from bovine lactoferrin shown specific antagonistic effects on TLR-8 (this thesis).
4. Galacto-oligosaccharides (GOS) have a non-microbial dependent effect on the secretory capacity of intestinal goblet cells. This effects is directly linked to the presence of β1→3 and β1→4 glycosidic linkages (this thesis).
5. The identification of the effects of the structural traits of lactose-derived oligosaccharides can lead to the customization of oligosaccharides mixtures for different nutraceutical
applications (this thesis).
6. The monosaccharide lactose present in GOS mixtures or in combination with 2’-fucosyllactose modulates the mRNA expression of genes involved in the production of intestinal mucus (this thesis).
7. The protective effects of 2’-fucosyllactose of the intestinal barrier can be explained by the direct interaction of this molecule with the intestinal epithelial cells (this thesis).
8. Which is more important? asked the panda, the journey or the destination? The company, said the little dragon. James Norbury
9. 七転び八起き
