University of Groningen
Virus:host interactions during chikungunya virus infection
Bouma, Ellen Marleen
DOI:
10.33612/diss.171018969
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bouma, E. M. (2021). Virus:host interactions during chikungunya virus infection: Analyzing host cell factors and antiviral strategies. University of Groningen. https://doi.org/10.33612/diss.171018969
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 1PDF page: 1PDF page: 1PDF page: 1
VIRUS:HOST INTERACTIONS
DURING CHIKUNGUNYA VIRUS
INFECTION
Analyzing host cell factors and antiviral strategies
by
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 2PDF page: 2PDF page: 2PDF page: 2
Copyright ©2021, Ellen Marleen Bouma
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and, when appropriate, the publisher holding the copyrights of the published articles.
The work described in this thesis was primarily performed in the department of Medical Microbiology and Infection Prevention of the University Medical Center Groningen and the University of Groningen, the Netherlands.
The research described in this thesis was partly financed by the Graduate School of Medical Sciences and by the Jan Kornelis de Kock foundation (Groningen). Printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the Groningen University.
Design by Pijlldesign, [email protected] Layout by Ellen M. Bouma
Printed by Ipskamp printing, Enschede Profile picture by Ilona Dijkstra Fotografie
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
Virus:host interactions during
chikungunya virus infection
Analyzing host cell factors and antiviral strategies
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op dinsdag 6 juli 2021 om 12.45 uur
door
Ellen Marleen Bouma
geboren op 12 oktober 1992 te Groningen
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 4PDF page: 4PDF page: 4PDF page: 4
Promotor
Prof. dr. J.M. Smit
Copromotor
Dr. I.A. Rodenhuis-Zybert
Beoordelingscommissie
Prof. dr. M.M. van Oers Prof. dr. B.J.L. Eggen Prof. dr. S. Mukhopadhyay
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 7PDF page: 7PDF page: 7PDF page: 7
Table of contents
Chapter 1
| 10
General introduction and scope of the thesis
Chapter
2
| 38
Mxra8 colocalizes with chikungunya virus during cell entry and membrane fusion
Chapter
3
| 62
Chikungunya virus requires an intact microtubule network for efficient viral genome delivery
Chapter
4
| 86
Serotonergic drugs inhibit chikungunya virus infection at different stages of the cell entry pathway
Chapter
5
| 112
Chikungunya virus replication cycle requires the Hsp70 network
Chapter
6
| 136
Cooperative chikungunya virus membrane fusion and its sub-stoichiometric inhibition by CHK-152 antibody
Chapter
7
| 176
Summarizing Discussion
Appendix
| 206
Nederlandse Samenvatting Acknowledgements
560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma 560817-L-bw-Bouma Processed on: 7-6-2021 Processed on: 7-6-2021 Processed on: 7-6-2021
Processed on: 7-6-2021 PDF page: 8PDF page: 8PDF page: 8PDF page: 8
