University of Groningen
Virus:host interactions during chikungunya virus infection
Bouma, Ellen Marleen
DOI:
10.33612/diss.171018969
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bouma, E. M. (2021). Virus:host interactions during chikungunya virus infection: Analyzing host cell factors and antiviral strategies. University of Groningen. https://doi.org/10.33612/diss.171018969
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VIRUS:HOST INTERACTIONS
DURING CHIKUNGUNYA VIRUS
INFECTION
Analyzing host cell factors and antiviral strategies
by
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Copyright ©2021, Ellen Marleen Bouma
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and, when appropriate, the publisher holding the copyrights of the published articles.
The work described in this thesis was primarily performed in the department of Medical Microbiology and Infection Prevention of the University Medical Center Groningen and the University of Groningen, the Netherlands.
The research described in this thesis was partly financed by the Graduate School of Medical Sciences and by the Jan Kornelis de Kock foundation (Groningen). Printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the Groningen University.
Design by Pijlldesign, info@pijlldesign.nl Layout by Ellen M. Bouma
Printed by Ipskamp printing, Enschede Profile picture by Ilona Dijkstra Fotografie
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Virus:host interactions during
chikungunya virus infection
Analyzing host cell factors and antiviral strategies
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op dinsdag 6 juli 2021 om 12.45 uur
door
Ellen Marleen Bouma
geboren op 12 oktober 1992 te Groningen
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Promotor
Prof. dr. J.M. Smit
Copromotor
Dr. I.A. Rodenhuis-Zybert
Beoordelingscommissie
Prof. dr. M.M. van Oers Prof. dr. B.J.L. Eggen Prof. dr. S. Mukhopadhyay
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Table of contents
Chapter 1
| 10
General introduction and scope of the thesis
Chapter
2
| 38
Mxra8 colocalizes with chikungunya virus during cell entry and membrane fusion
Chapter
3
| 62
Chikungunya virus requires an intact microtubule network for efficient viral genome delivery
Chapter
4
| 86
Serotonergic drugs inhibit chikungunya virus infection at different stages of the cell entry pathway
Chapter
5
| 112
Chikungunya virus replication cycle requires the Hsp70 network
Chapter
6
| 136
Cooperative chikungunya virus membrane fusion and its sub-stoichiometric inhibition by CHK-152 antibody
Chapter
7
| 176
Summarizing Discussion
Appendix
| 206
Nederlandse Samenvatting Acknowledgements
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