University of Groningen
Virus:host interactions during chikungunya virus infection
Bouma, Ellen Marleen
DOI:
10.33612/diss.171018969
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bouma, E. M. (2021). Virus:host interactions during chikungunya virus infection: Analyzing host cell factors and antiviral strategies. University of Groningen. https://doi.org/10.33612/diss.171018969
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Stellingen
Behorende bij het proefschrift
Virus:host interactions during chikungunya virus infection
Analyzing host cell factors and antiviral strategies
1. Understanding the biology of the cell is a prerequisite for studying the virus replication cycle. 2. Host-directed antivirals inhibiting virus disassembly post membrane fusion but prior to RNA
release, reveal how little we know about the process of nucleocapsid uncoating.
3. Based on the discrepancy between the number of antiviral compounds described in literature and the number of effective antiviral therapies in the clinic, it is evident that the virus replication cycle in the host cell is not yet well-enough understood and more basic research is needed for the development of effective antiviral compounds.
4. The current SARS-CoV-2 pandemic reminds us of the possible collaboration –within both academia and industry– that we should cherish and exploit for future scientific questions in the field of emerging infectious diseases.
5. Basic scientific research over the past decades have made it possible to produce vaccines within 12-months after the onset of a newly emerged infectious disease; therefore basic scientific research and innovation should always be a priority in future governmental strategies. 6. Emerging viruses are only of interest to the public when it knocks on their own front door. 7. Results are results, there is no negative or positive in there.
8. Treating PhD-candidates as students will limit them in their professional career mindset. Universities should spend more time in coaching these young professionals to identify their natural competencies and gifts and cultivate these. There are hundreds and hundreds of ways to succeed and many, many different abilities that will help you get there.
(Based on Howard Gardner in Frames of Mind)
9. An important asset of a scientist, which one should never forget, is to stay critical and to keep reflecting its own ideas.
10. One should always remember the sentences ‘it is what it is’ and ‘there is a solution to every problem’ when starting a PhD trajectory.
