University of Groningen
Molecular dissection of Staphylococcus aureus virulence Zhao, Xin
DOI:
10.33612/diss.123240192
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Publication date: 2020
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Zhao, X. (2020). Molecular dissection of Staphylococcus aureus virulence. University of Groningen. https://doi.org/10.33612/diss.123240192
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Molecular dissection of Staphylococcus aureus virulence
The work described in this thesis was performed in the Laboratory of Molecular Bacteriology, Department of Medical Microbiology of the University of Groningen and the University Medical Center Groningen (The Netherlands)
The studies presented in this thesis were supported by the China Scholarship Council grant 201506170036 and the Graduate School of Medical Sciences of the University of Groningen. Printing of this thesis was supported by the Graduate School of Medical Sciences of the University of Groningen.
Molecular dissection of Staphylococcus aureus virulence
Dissertation of the University of Groningen
ISBN: 978-94-034-2645-7 (print) ISBN: 978-94-034-2644-0 (digital)
Cover photo: Confocal fluorescence microscopy image of HeLa cells exposed to
Staphylococcus aureus ATCC 12600
Printed by: Gildeprint, the Netherlands
Copyright © Xin Zhao, 2020. All rights reserved. No part of this thesis may be reproduced,
stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
Molecular dissection of Staphylococcus aureus virulence
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans.
This thesis will be defended in public on
Friday 1 May 2020 at 16:15 hours
by
Xin Zhao
born on 27 April 1987 in Shandong, China
Supervisor
Prof. J.M. van Dijl
Co-supervisor
Dr. G. Buist
Assessment committee
Prof. S. Hammerschmidt Prof. A.J.M. Driessen Prof. O.P. Kuipers
Paranymphs
Min Wang
Table of Contents
Chapter 1: General Introduction and Scope of this Thesis. 7
Chapter 2: Exoproteome Heterogeneity among closely related Staphylococcus aureus t437 Isolates and Possible Implications for Virulence. Published in the Journal of Proteome Research, 2019, 18(7): 2859-2874 25
Chapter 3: Exoproteomic Profiling Uncovers Critical Determinants for Virulence of Livestock-associated and Human-originated Staphylococcus aureus ST398 Strains. 63
Chapter 4: Pathogen-pathogen Interactions in the Microbiome, a way to Soothe Virulence? 99
Chapter 5: General Summarizing Discussion. 132
Chapter 6: Nederlandse samenvatting 145
List of publications 160 Biography 161 Acknowledgements 162
