University of Groningen The gut microbiota in cardiovascular disease Brandsma, Eelke Thijs

University of Groningen

The gut microbiota in cardiovascular disease

Brandsma, Eelke Thijs

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2019

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Brandsma, E. T. (2019). The gut microbiota in cardiovascular disease: Interactions between the diet,

microbiota and the gut immune barrier. Rijksuniversiteit Groningen.

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The gut microbiota in

cardiovascular disease

Interactions between the diet, microbiota

and the gut immune barrier

Research

The research described in this thesis was performed in the department

of Pediatrics, section Molecular Genetics at the University Medical

Centre Groningen, University of Groningen, Groningen, the Netherlands.

Funding

The research described in this thesis was funded by a grant from

Cardio-Vasculair Onderzoek Nederland (CVON2012-03) and by the Jan Kornelis

de Cock Foundation.

Copyright © 2019 Eelke Brandsma

No part of this this book may be reproduced, stored in retrieval systems

or transmitted in any form or by any means without prior permission of

the author or, when applicable, the publisher holding the copyright of the

published articles

The gut microbiota in

cardiovascular disease

Interactions between the diet, microbiota and

the gut immune barrier

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 27 februari 2019 om 12.45 uur

door

Eelke Thijs Brandsma

geboren op 16 juli 1987

te Heerenveen

Promotor

Dr. ing. A.J.A. van de Sluis

Copromotor

Dr. D.P.Y. Koonen

Beoordelingscommissie

Prof. dr. K.N. Faber

Prof. dr. A.K. Groen

Prof. dr. L. Joosten

Promotor

Dr. ing. A.J.A. van de Sluis

Copromotor

Dr. D.P.Y. Koonen

Beoordelingscommissie

Table of contents

Chapter 1

Introduction

Chapter 2

The immunity-diet-microbiota axis in the

development of metabolic syndrome

Curr Opin Lipidol. 2015 Apr;26(2):73-81

Chapter 3

A pro-inflammatory gut microbiota increases

systemic inflammation and accerlarates

atherosclerosis

Circ Res. 2019;124:94-100

Chapter 4

A protective role for the antimicrobial peptide

REG3γ in atherogenesis

Chapter 5

The gut anti-inflammatory agent 5-ASA does

not protect against insulin resistance in mice

Chapter 6

General discussion

Summary

Samenvatting

Dankwoord

List of publications

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