University of Groningen
Intestinal nuclear receptors in control of energy metabolism
Zwarts, Irene
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Publication date: 2019
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Zwarts, I. (2019). Intestinal nuclear receptors in control of energy metabolism. Rijksuniversiteit Groningen.
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The research described in this thesis was conducted at the department of Pediatrics, section Molecular Metabolism and Nutrition, University Medical Center Groningen, The Netherlands, and funded by Netherlands Organisation for Scientific Research (NWO) and by the Jan Kornelis de Cock stichting. Printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, and Graduate School of Medical Sciences, research Institute for Drug Exploration (GUIDE).
Irene Zwarts
Intestinal nuclear receptors in control of energy metabolism PhD dissertation, University of Groningen, The Netherlands
Cover design: Irene Zwarts Layout: Irene Zwarts
Printed by: Ridderprint B.V., Ridderkerk, The Netherlands ISBN (printed): 978-94-034-1277-1
ISBN (digital): 978-94-034-1276-4 Copyright©2018 Irene Zwarts
All rights reserved. No part of this publication may be reproduced, distributed, stored in retrieval system or transmitted, in any form or by any means, without permission of the author and the publisher holding respective copyrights of the published articles, if applicable.
Intestinal nuclear receptors in
control of energy metabolism
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 16 januari 2019 om 12.45 uur
door
Irene Zwarts
geboren op 1 september 1989 te Groningen
Promotores
Prof. dr. J.W. Jonker Prof. dr. H.J. VerkadeBeoordelingscommissie
Prof. dr. G.J. NavisProf. dr. E.M. van der Beek Prof. dr. R. Shiri-Sverdlov
Paranimfen
Tim van Zutphen Suruchi NepalContents
Chapter 1 General Introduction 9
Chapter 2 Distinct effects of glucose and fructose on intestine and 31 liver transcriptomes in mice
Chapter 3 Identification of transcriptional regulators of the 59 GLUT-family of sugar transporters
Chapter 4 Identification of the fructose transporter GLUT5 (SLC2A5) 89 as a novel target of nuclear receptor LXR
Chapter 5 Regulation and expression of the putative intestinal 117 hexose transporter GLUT7 (SLC2A7)
Chapter 6 Intestinal PPARd protects against diet-induced obesity, 137 insulin resistance and dyslipidemia
Chapter 7 General Discussion 161
Appendices 177 English summary 178 Nederlandse samenvatting 182 Acknowledgements/ Dankwoord 186 Biography/ Biografie 189 List of publications 191
