University of Groningen
Disorders of bilirubin and lipid metabolism
Blankestijn, Maaike
DOI:
10.33612/diss.168960021
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Publication date: 2021
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Blankestijn, M. (2021). Disorders of bilirubin and lipid metabolism: models and targets of intervention. University of Groningen. https://doi.org/10.33612/diss.168960021
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Disorders of bilirubin and lipid metabolism
models and targets of intervention
Maaike Blankestijn
The research described in this thesis was carried out at the Laboratory of Pediatrics, Section Molecular Metabolism and Nutrition, University Medical Center Groningen, the Netherlands. The research was funded by grants from The Netherlands Organization for Scientific Research (VICI grant 016.176.640 to Johan W. Jonker) and De Cock Stichting. The printing of this thesis was financially supported by the University of Groningen and the Graduate School of Medical Sciences, Research Institute for Drug Exploration (GUIDE).
Cover design: Rick Blankestijn
Publisher: University of Groningen, Groningen, the Netherlands Printing: Ridderprint, www.ridderprint.nl
Paranimphs: Alain Dekker & Iris Drent Copyright © Maaike Blankestijn, Oldenzaal 2021.
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system of any nature, or transmitted in any form or by any means, without permission of the author and the publisher holding respective copyrights of the published articles, if applicable.
Disorders of bilirubin and lipid
metabolism
Models and targets of intervention
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 31 mei 2021 om 11.00 uur
door
Maaike Blankestijn
geboren op 27 oktober 1990 te Hengelo (OV)Promotores
Prof. dr. H.J. Verkade Prof. dr. J.W. JonkerBeoordelingscommissie
Prof. dr. F.J. van Spronsen Prof. dr. R.H.J. Houwen Prof. dr. I.P. Kema‘’As science struggles on
To try to explain
Oxytoxins flowing
Ever into my brain’’
(Overpowered – Roisin Murphy)
Contents
Chapter 1 General introduction 9
Chapter 2 Characterization of the hyperbilirubinemic and
hypocholesterolemic phenotype of the UGT1A1j/BluHsdRrrc
Gunn rat strain
55
Chapter 3 Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats
77
Chapter 4 Peroxisomal function is not impaired in mice with a deficiency
in the Peroxisome Proliferator-Activated Receptor Alpha target gene PXMP4
99
Chapter 5 Short-term protein restriction at advanced age stimulates FGF21
signalling, energy expenditure and browning of white adipose tissue
123
Chapter 6 General discussion and conclusion 163
Appendices 187 Summary 189 Samenvatting 195 Dankwoord 201 Curriculum Vitae 205 List of publications 207
