University of Groningen
In vitro approaches for the evaluation of human vaccines
Signorazzi, Aurora
DOI:
10.33612/diss.166150822
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Signorazzi, A. (2021). In vitro approaches for the evaluation of human vaccines. University of Groningen. https://doi.org/10.33612/diss.166150822
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In vitro approaches for the
evaluation of human vaccines
Aurora Signorazzi
In vitro approaches for the evaluation of human vaccines
Copyright © 2021, Aurora Signorazzi
The work described in this thesis was performed at the Laboratory of Vaccinology, department of Medical Microbiology and Infection Prevention of the University Medical Center Groningen, University of Groningen (the Netherlands).
Printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the Groningen University Library.
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without written permission of the author and, when appropriate, the publisher holding the copyrights of the published articles.
Layout by Aurora Signorazzi
Cover by Peter Greenwood – www.peter-greenwood.com
In vitro approaches for the
evaluation of human vaccines
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 19 May 2021 at 11.00 hours
by
Aurora Signorazzi
born on 13 February 1990
in Rome, Italy
Supervisor
Prof. A.L.W. Huckriede
Co-supervisor
Prof. I.A. Rodenhuis-Zybert
Assessment Committee
Prof. F. Broere
Prof. A. Salvati
Table of contents
Chapter 1
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9 General introduction and scope of this thesisChapter 2
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37Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis vaccine
Chapter 3
_________________________________________
71In vitro assessment of tick-borne encephalitis vaccine: suitable human cell platforms and potential biomarkers
Chapter 4
________________________________________
103Transcriptional profiling of TBE vaccine-stimulated human PBMCs: a path from pattern recognition receptors to interferon signaling
Chapter 5
________________________________________
139Inactivated or damaged? Comparing the effect of inactivation methods on influenza virions to optimize vaccine production
Chapter 6
