University of Groningen
In vitro approaches for the evaluation of human vaccines
Signorazzi, Aurora
DOI:
10.33612/diss.166150822
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Signorazzi, A. (2021). In vitro approaches for the evaluation of human vaccines. University of Groningen. https://doi.org/10.33612/diss.166150822
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Stellingen behorende bij het proefschrift
In vitro approaches for the
evaluation of human vaccines
Aurora Signorazzi
1. Vaccination is one the most important advancements in history; thanks to vaccines, the eradication of diseases that have plagued humanity for millennia or the swift defeat of a global pandemic are finally realistic prospects. (This thesis)
2. The application of the knowledge derived from a systems biology approach to vaccine research and the use of novel omics techniques allow us to consider more relevant human-derived in vitro platforms as alternative to the current animal models. (This thesis)
3. A primary cell-based system can successfully be included in an array of in vitro methods for release testing of non-adjuvanted TBE vaccine batches. (This thesis)
4. Activation of the type I interferon pathway in peripheral blood mononuclear cells is an unequivocal signature of both the TBE vaccine and the live virus. (This thesis)
5. In the production of whole inactivated virus vaccines, the preservation of the viral genome is paramount as this feature provides important self-adjuvanting properties to the formulation. (This thesis)
6. As the interest in replacing (or at least reducing) animal testing is increasing in all sectors involved in the vaccine industry, the implementation of cell-based methods for batch potency assessment is a question of when, not if. (This thesis)
7. “If we knew what it was we were doing, it would not be called research, would it?” – Albert Einstein
8. “Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has.” – Margaret Mead
