University of Groningen
Interplay between dietary fibers and gut microbiota for promoting metabolic health Mistry, Rima
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Publication date: 2019
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Mistry, R. (2019). Interplay between dietary fibers and gut microbiota for promoting metabolic health. University of Groningen.
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Interplay between dietary
fibers and gut microbiota for
promoting metabolic health
© Rima H Mistry | 2019
The work described in this thesis is performed at the Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Cover: Cover image by Rima H Mistry, designed by Art Forest Design Layout: Rima H Mistry
Printed by: ProefschriftMaken ISBN:
978-94-034-1503-1 (printed) 978-94-034-1502-4 (digital)
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval database, or transmitted in any form or by any means, without prior permission of the author.
Interplay between dietary fibers and gut
microbiota for promoting metabolic health
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 27 March 2019 at 11.00 hours
by
Rima Harkishan Mistry
born on 24 July 1988 in Dar es Salaam, Tanzania
Supervisor Prof. H.J. Verkade Co-supervisor Dr. U.J.F. Tietge Assessment Committee Prof. R.M.F Berger Prof. P. de Vos Prof. J. Knol
Dedicated to my mother and father for all their love, support and sacrifice without which I would not have made this far.
Paranymphs
M.A.M. Lohuis M.Z.A. Alimohamed
The research project described in this thesis was performed in the public-private partnership CarboHealth coordinated by the Carbohydrate Competence Center and financed by participating partners and allowances of the TKI Agri&Food program, Ministry of Economic Affairs.
Printing of this thesis is financially supported by: Groningen graduate school of science (GSMS) University of Groningen
CONTENTS
Chapter 1 General Introduction. . . .1
Chapter 2 Effect of the prebiotic fiber inulin on cholesterol metabolism in wildtype mice. . . .23
Chapter 3 Dietary isomalto/malto-polysaccharides increase fecal bulk and microbial fermentation . . . .39
Chapter 4 Reverse cholesterol transport is increased in germ-free mice. . . .59
Chapter 5 Absence of intestinal microbiota increases ß-cyclodextrin stimulated reverse cholesterol transport. . . .71
Chapter 6 Galacto-oligosaccharides supplementation decreases obesity and improves insulin sensitivity in mice fed a Western-type diet . . . .91
Chapter 7 General discussion. . . .113
Summary . . . .125
Nederlandse Samenvatting . . . .129
Acknowledgements . . . .133
Biography . . . .137
