University of Groningen
Molecular dissection of Staphylococcus aureus virulence Zhao, Xin
DOI:
10.33612/diss.123240192
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
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Zhao, X. (2020). Molecular dissection of Staphylococcus aureus virulence. University of Groningen. https://doi.org/10.33612/diss.123240192
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Propositions accompanying the thesis
Molecular dissection of Staphylococcus aureus virulence
1. The ability of S. aureus to cause infections relates to the combined expression of a wide variety of virulence factors (Chapters 2 and 3).
2. Genome-based typing methods are useful epidemiological tools, but they are inadequate for characterizing the virulence of closely related staphylococcal isolates with different epidemiology (Chapters 2 and 3).
3. High-throughput proteomics is a particularly powerful tool to explore bacterial virulence factor production, especially since most virulence factors are secreted into the extracellular milieu of the bacteria (Chapters 2 and 3).
4. The degree of exoproteome heterogeneity in different groups of clinical S. aureus isolates depends on the respective lineage, their geographical distribution, and/or the hosts from which they were collected (Chapters 2 and 3).
5. Prophage activity contributes to the excretion of extracellular cytoplasmic proteins in many clinical isolates of S. aureus (Chapters 2 and 3).
6. Studies on the interactions between S. aureus and other bacteria in the natural host ecosystem will lead to a better understanding of the triggers that transform S. aureus from a harmless colonizer into an allergen or a deadly pathogen (Chapter 4).
7. The proteins IsaA, PVL, Sbi and SpA are relevant targets for novel preventive or therapeutic anti-staphylococcal interventions, but they also represent indicators for high-risk transmissible clones (Chapters 2, 3 and 5).
8. Understanding the diversity of S. aureus responses to the different conditions in the human host is an important prerequisite for development of long-lasting and sustainable anti-staphylococcal therapies.
