University of Groningen
On the role of macrophages, microglia and the extracellular matrix in remyelination Wang, Peng
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wang, P. (2018). On the role of macrophages, microglia and the extracellular matrix in remyelination. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
1
On the role of macrophages, microglia
and the extracellular matrix in
remyelination
2
Research presented in this thesis was performed at the Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
The rseearch conducted in this thesis was financially supported by the China Scholarship Council (CSC)
Dutch MS Research Foundation (Stchting MS Research)
Printing was supported by:
University Medical Center Groningen University of Groningen
Stichting MS Research
Research School of Behavioural and Cognitive Neuroscience (BCN)
Cover and layout by P. Wang and C. Yan Printed by Ipskamp Drukkers
© 2018 P. Wang. All right reserved. No part of this book may be reproduced or transmitted in any form or by any means without prior permission of the authors.
ISBN: 978-94-034-0450-9 (electronic version) ISBN: 978-94-034-0451-6 (Printed version)
3
On the role of macrophages,
microglia and the extracellular
matrix in remyelination
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Wednesday 28 March 2018 at 16.15 hours
by
Peng Wang
born on 15 February 19874 Supervisor Prof. D. Hoekstra Co-supervisor Dr. W. Baron Assessment committee Prof. B.J.L. Eggen Prof. F.G.M. Kroese Prof. N. Hellings
5
Paranimfen
Sun Yue Karin Klappe
7
9
Contents
Chapter 1 Remodelling of the extracellular matrix in multiple sclerosis lesions: Implications for remyelination
Chapter 2 MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions
Chapter 3 Fibronectin aggregates promote features of a classically- and alternatively-activated phenotype in macrophages
Chapter 4
Chapter 5 IL-4 overcomes fibronectin aggregate- mediated inhibition of remyelination in organotypic forebrain slice cultures
Chapter 6 Summary and Perspectives
Abbreviations 213 149 187 105 11 63 Acknowledgement Nederlandse Samenvatting 227 235 241 ECM molecules prevent the generation of OPC
differentiation-supporting macrophages and microglia in the absence of appropriate anti-inflammatory signals
