Cover Page
The handle
http://hdl.handle.net/1887/137852
holds various files of this Leiden
University dissertation.
Author: Salgado, C.
Epigenetic Alterations in the
Predisposition to
and Progression of Melanoma
The research presented in this thesis was performed at the Departments of Dermatology, Cell and Chemical Biology and Ophthalmology of the Leiden University medical Center (LUMC) and was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 641458.
ISBN: 978-94-6419-032-8
Cover design and layout: Ilse Modder (www.ilsemodder.nl) Printed by: Gildeprint Enschede (www.gildeprint.nl)
Epigenetic Alterations in the
Predisposition to
and Progression of Melanoma
Proefschriftter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr.C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op
woensdag 21 oktober 2020 klokke 12.30 uur
Promotor Prof.dr. M.H. Vermeer Co-promotores Dr. R. van Doorn Dr. N.A. Gruis Leden Promotiecommissie Prof. dr. J Morreau
I am among those who think
that science has great beauty.
TABLE OF CONTENTS
Chapter 1 General introduction
Chapter 2 A novel germline variant in the DOT1L gene Co-segregating in a Dutch family with a history of melanoma
Chapter 3 Genome-wide analysis of constitutional DNA methylation in familial melanoma
Chapter 4 Genome-wide characterization of 5-hydroxymethylcytosine in melanoma reveals major differences with nevus
Chapter 5 Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression
Chapter 6 Summary and discussion
Addendum Nederlandse samenvatting Resumo em Português List of publications About the author
